| Gene Symbol | Mesp2 |
|---|---|
| Entrez Gene | 17293 |
| Alt Symbol | bHLHc6 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | mesoderm posterior 2 |
| Other Description | mesoderm posterior protein 2 |
| Swissprots | Q3UIV5 O08574 |
| Accessions | EDL07045 O08574 AK146740 BAE27401 BC145652 AAI45653 BC145654 AAI45655 U71125 AAB51199 NM_008589 NP_032615 |
| Function | Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. May play a role with Tcf15 in the differentiation of myotomal and sclerotomal cells by regulating Pax family genes. Controls also the expression of the protocadherin PCDH8/PAPC, EPHA4, RIPPLY2, NOTCH2, FGFR1, and CER1. Binds to the E-boxes within the EPH4A and RIPPLY2 enhancers. {ECO:0000269|PubMed:10887078, ECO:0000269|PubMe |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:15902259, ECO:0000269|PubMed:16996494}. |
Recombinant Mouse Mesoderm posterior protein 2(Mesp2) - CSB-YP013710MO CSB-EP013710MO CSB-BP013710MO CSB-MP013710MO from Cusabio
|
||||||||||
Mesoderm posterior protein 2 (Mesp2), Recombinant Protein - MBS1207288 from MyBioSource
|