Mesp2

Gene Symbol Mesp2
Entrez Gene 17293
Alt Symbol bHLHc6
Species Mouse
Gene Type protein-coding
Description mesoderm posterior 2
Other Description mesoderm posterior protein 2
Swissprots Q3UIV5 O08574
Accessions EDL07045 O08574 AK146740 BAE27401 BC145652 AAI45653 BC145654 AAI45655 U71125 AAB51199 NM_008589 NP_032615
Function Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. May play a role with Tcf15 in the differentiation of myotomal and sclerotomal cells by regulating Pax family genes. Controls also the expression of the protocadherin PCDH8/PAPC, EPHA4, RIPPLY2, NOTCH2, FGFR1, and CER1. Binds to the E-boxes within the EPH4A and RIPPLY2 enhancers. {ECO:0000269|PubMed:10887078, ECO:0000269|PubMe
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:15902259, ECO:0000269|PubMed:16996494}.

MESP2 CRISPR/Cas9 KO Plasmid (m) - sc-421633 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

MESP2 HDR Plasmid (m) - sc-421633-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

MESP2 Double Nickase Plasmid (m) - sc-421633-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

MESP2 Double Nickase Plasmid (m2) - sc-421633-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

MESP2 CRISPR Activation Plasmid (m) - sc-421633-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

MESP2 CRISPR Activation Plasmid (m2) - sc-421633-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

MESP2 Lentiviral Activation Particles (m) - sc-421633-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

MESP2 Lentiviral Activation Particles (m2) - sc-421633-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

MESP2 siRNA (m) - sc-149374 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MESP2 shRNA Plasmid (m) - sc-149374-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MESP2 shRNA (m) Lentiviral Particles - sc-149374-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU090641 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN35472 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND35472 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MESP2 siRNA (Mouse) - CRM2524 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse MESP2 (NM_008589.2) - SHH340527 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Mesp2(NM_008589.2) - SHH185105 from Creative biogene

Category siRNA
Species Reactivities Mouse

MESP2 shRNA Plasmid (Mouse) - CHM2524 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

MESP2 miRNA 3'UTR clone - MiUTR1M-07055 from Creative biogene

Species Reactivities Mouse
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