SMUG1

Gene Symbol SMUG1
Entrez Gene 23583
Alt Symbol FDG, HMUDG, UNG3
Species Human
Gene Type protein-coding
Description single-strand-selective monofunctional uracil-DNA glycosylase 1
Other Description single-strand selective monofunctional uracil DNA glycosylase
Swissprots A8K2K9 Q0D2M0 Q53HV7 Q9BWC8 Q8NB71 O95862
Accessions AAL86910 CAE89209 EAW96752 EAW96753 EAW96754 EAW96755 EAW96756 EAW96757 Q53HV7 AF125182 AAD17301 AI002776 AK001235 BAA91571 AK001789 AK091468 BAC03670 AK222473 BAD96193 AK290274 BAF82963 BC000417 AAH00417 BC088352 AAH88352 BC105607 AAI05608 BG706635 BG764502 BU195802 CD245413 DA430734 DA703553 XM_006719319 XP_006719382 XM_006719320 XP_006719383 XM_006719321 XP_006719384 XM_006719322 XP_006719385 XM_011538109 XP_011536411 XM_011538110 XP_011536412 XM_011538111 XP_011536413 XM_011538112 XP_011536414 XM_011538113 XP_011536415 XM_011538114 XP_011536416 XM_011538115 XP_011536417 XM_011538116 XP_011536418 XM_011538117 XP_011536419 XM_011538118 XP_011536420 XM_011538119 XP_011536421 XM_011538120 XP_011536422 XM_011538121 XP_011536423 XM_011538122 XP_011536424 XM_011538123 XP_011536425 NM_001243787 NP_001230716 NM_001243788 NP_001230717 NM_001243789 NP_001230718 NM_001243790 NP_001230719 NM_001243791 NP_001230720 NM_014311 NP_055126 NR_045039
Function Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. The activity is greater against mismatches (U/G) than against matches (U/A). Excised uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5- hydroxymethyluracil (hmU)] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. The general order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at the low salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNA. {ECO:0000269|PubMed:10074426, ECO:0000269|PubMed:11526119, ECO:0000269|PubMed:12161446, ECO:0000269|PubMed:12718543}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10074426, ECO:0000269|PubMed:12161446}.
Top Pathways Base excision repair

SMUG1 (A-1) - sc-514343 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SMUG1 (A-1): sc-514343. Western blot analysis of SMUG1 expression in HeLa (A), SJRH30 (B) and K-562 (C) whole cell lysates.

SMUG1 (D-2) - sc-377370 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SMUG1 (D-2): sc-377370. Western blot analysis of SMUG1 expression in non-transfected: sc-117752 (A) and mouse SMUG1 transfected: sc-123667 (B) 293T whole cell lysates.

SMUG1 (H-11) - sc-271580 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SMUG1 (H-11): sc-271580. Western blot analysis of SMUG1 expression in non-transfected: sc-117752 (A) and mouse SMUG1 transfected: sc-123667 (B) 293T whole cell lysates.

SMUG1 (H-135) - sc-292616 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SMUG1 (H-135): sc-292616. Western blot analysis of SMUG1 expression in non-transfected: sc-117752 (A) and mouse SMUG1 transfected: sc-123667 (B) 293T whole cell lysates.

SMUG1 (H-55) - sc-98849 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SMUG1 (H-55): sc-98849. Western blot analysis of SMUG1 expression in non-transfected 293T: sc-117752 (A), mouse SMUG1 transfected 293T: sc-123667 (B) and Jurkat (C) whole cell lysates.

SMUG1 (N-19) - sc-26878 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SMUG1 (N-19): sc-26878. Western blot analysis of SMUG1 expression in non-transfected: sc-117752 (A) and mouse SMUG1 transfected: sc-123667 (B) 293T whole cell lysates.

SMUG1 (C-12) - sc-26880 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SMUG1 (C-12): sc-26880. Western blot analysis of SMUG1 expression in non-transfected: sc-117752 (A) and mouse SMUG1 transfected: sc-123667 (B) 293T whole cell lysates.

Anti-SMUG1 antibody - ab15716 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SMUG1 antibody - ab115572 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Human Brain Cortex tissue (formalin-fixed, paraffin-embedded) stained with ab115572 at 2.5 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-SMUG1 antibody - ab110518 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SMUG1 antibody (ab110518) at 1/500 dilutionLane 1 : 293 cell lysateLane 2 : COS7 cell lysateLane 3 : Immunizing peptide

Anti-SMUG1 antibody - ab168276 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-SMUG1 antibody (ab168276) at 1 µg/mlLane 1 : SMUG1 transfected 293T lysateLane 2 : Non transfected 293T lysateLysates/proteins at 15 µl per lane.

Anti-SMUG1 antibody [EPR15624] - ab192240 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15624
Western blot analysis of immunoprecipitation pellet from 293 cell lysate immunoprecipitated using ab192240 at 1/100 dilution (lane 1) or PBS control (lane 2).Secondary: Anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1500 dilution.

Anti-SMUG1 antibody - N-terminal - ab187123 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SMUG1 antibody - N-terminal (ab187123) at 1/1000 dilution + HeLa cell extract

Anti-SMUG1 antibody - N-terminal - ab173211 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SMUG1 antibody - N-terminal (ab173211) at 1/100 dilution + K562 cell lysate at 35 µg

Anti-SMUG1 Antibody (aa43-71, APC) - LS-C207670 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMUG1 Antibody (aa43-71, AP) - LS-C207669 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMUG1 Antibody (aa43-71, Biotin) - LS-C207671 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMUG1 Antibody (aa43-71, FITC) - LS-C207672 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMUG1 Antibody (aa43-71, Azide-free, HRP) - LS-C207673 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMUG1 Antibody (aa43-71, PE) - LS-C207674 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMUG1 Antibody (aa137-182) - LS-C313788 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SMUG1 Antibody (aa110-159) - LS-C81981 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Hela cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-SMUG1 Antibody (aa42-71) - LS-C325216 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMUG1 Antibody (aa43-71) - LS-C159045 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SMUG1 Antibody western blot of K562 cell line lysates (35 ug/lane). The SMUG1 antibody detected the SMUG1 protein (arrow).

Anti-SMUG1 Antibody (aa2-14) IHC-plus™ - LS-B2587 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-SMUG1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2587 concentration 5 ug/ml.
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