| Gene Symbol |
SMUG1
|
| Entrez Gene |
23583
|
| Alt Symbol |
FDG, HMUDG, UNG3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
single-strand-selective monofunctional uracil-DNA glycosylase 1
|
| Other Description |
single-strand selective monofunctional uracil DNA glycosylase
|
| Swissprots |
A8K2K9 Q0D2M0 Q53HV7 Q9BWC8 Q8NB71 O95862
|
| Accessions |
AAL86910 CAE89209 EAW96752 EAW96753 EAW96754 EAW96755 EAW96756 EAW96757 Q53HV7 AF125182 AAD17301 AI002776 AK001235 BAA91571 AK001789 AK091468 BAC03670 AK222473 BAD96193 AK290274 BAF82963 BC000417 AAH00417 BC088352 AAH88352 BC105607 AAI05608 BG706635 BG764502 BU195802 CD245413 DA430734 DA703553 XM_006719319 XP_006719382 XM_006719320 XP_006719383 XM_006719321 XP_006719384 XM_006719322 XP_006719385 XM_011538109 XP_011536411 XM_011538110 XP_011536412 XM_011538111 XP_011536413 XM_011538112 XP_011536414 XM_011538113 XP_011536415 XM_011538114 XP_011536416 XM_011538115 XP_011536417 XM_011538116 XP_011536418 XM_011538117 XP_011536419 XM_011538118 XP_011536420 XM_011538119 XP_011536421 XM_011538120 XP_011536422 XM_011538121 XP_011536423 XM_011538122 XP_011536424 XM_011538123 XP_011536425 NM_001243787 NP_001230716 NM_001243788 NP_001230717 NM_001243789 NP_001230718 NM_001243790 NP_001230719 NM_001243791 NP_001230720 NM_014311 NP_055126 NR_045039
|
| Function |
Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. The activity is greater against mismatches (U/G) than against matches (U/A). Excised uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5- hydroxymethyluracil (hmU)] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. The general order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at the low salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNA. {ECO:0000269|PubMed:10074426, ECO:0000269|PubMed:11526119, ECO:0000269|PubMed:12161446, ECO:0000269|PubMed:12718543}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10074426, ECO:0000269|PubMed:12161446}.
|
| Top Pathways |
Base excision repair
|
