SMUG1

Gene Symbol	SMUG1
Entrez Gene	23583
Alt Symbol	FDG, HMUDG, UNG3
Species	Human
Gene Type	protein-coding
Description	single-strand-selective monofunctional uracil-DNA glycosylase 1
Other Description	single-strand selective monofunctional uracil DNA glycosylase
Swissprots	A8K2K9 Q0D2M0 Q53HV7 Q9BWC8 Q8NB71 O95862
Accessions	AAL86910 CAE89209 EAW96752 EAW96753 EAW96754 EAW96755 EAW96756 EAW96757 Q53HV7 AF125182 AAD17301 AI002776 AK001235 BAA91571 AK001789 AK091468 BAC03670 AK222473 BAD96193 AK290274 BAF82963 BC000417 AAH00417 BC088352 AAH88352 BC105607 AAI05608 BG706635 BG764502 BU195802 CD245413 DA430734 DA703553 XM_006719319 XP_006719382 XM_006719320 XP_006719383 XM_006719321 XP_006719384 XM_006719322 XP_006719385 XM_011538109 XP_011536411 XM_011538110 XP_011536412 XM_011538111 XP_011536413 XM_011538112 XP_011536414 XM_011538113 XP_011536415 XM_011538114 XP_011536416 XM_011538115 XP_011536417 XM_011538116 XP_011536418 XM_011538117 XP_011536419 XM_011538118 XP_011536420 XM_011538119 XP_011536421 XM_011538120 XP_011536422 XM_011538121 XP_011536423 XM_011538122 XP_011536424 XM_011538123 XP_011536425 NM_001243787 NP_001230716 NM_001243788 NP_001230717 NM_001243789 NP_001230718 NM_001243790 NP_001230719 NM_001243791 NP_001230720 NM_014311 NP_055126 NR_045039
Function	Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. The activity is greater against mismatches (U/G) than against matches (U/A). Excised uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5- hydroxymethyluracil (hmU)] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. The general order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at the low salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNA. {ECO:0000269|PubMed:10074426, ECO:0000269|PubMed:11526119, ECO:0000269|PubMed:12161446, ECO:0000269|PubMed:12718543}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:10074426, ECO:0000269|PubMed:12161446}.
Top Pathways	Base excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SMUG1 full length protein - ab132162 from Abcam Category Protein Source Wheat germ Species Human

Human SMUG1 full length protein - ab139227 from Abcam Category Protein Source E. coli Species Human

Human SMUG1 peptide - ab23269 from Abcam Category Peptide Species Human

SMUG1 Antibody Blocking Peptide - LS-E5020 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SMUG1 Antibody Blocking Peptide - LS-E25699 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SMUG1 Antibody Blocking Peptide - LS-E19853 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SMUG1 Recombinant Protein - H00023583-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SMUG1 Partial Recombinant Protein - H00023583-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant E. coli SMUG1 Protein - NBP2-22646 from Novus Biologicals Category Protein Prices $269.00 Sizes 50 µg Source E.coli

Recombinant Human SMUG1 Protein - NBP2-22806 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

SMUG1-Antibody-N-term-Blocking-Peptide - BP17422a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SMUG1 blocking peptide - GTX15716-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Human SMUG1 protein - orb169305 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Human SMUG1 protein - orb246567 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

SMUG1 Blocking Peptide - 33R-4200 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SMUG1 protein (His tag) - 30R-2912 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

SMUG1 Blocking Peptide - abx063779 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

SMUG1 Peptide - AC21-0529-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SMUG1 (1-270, His-tag) - AR50672PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

SMUG1 (1-270, His-tag) - AR50672PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

SMUG1 - H00023583-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SMUG1 - H00023583-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SMUG1 - H00023583-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SMUG1 - H00023583-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SMUG1, 1-270aa, Human, His tag, E.coli - 01-P1848 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

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