PIWIL2

Gene Symbol	PIWIL2
Entrez Gene	55124
Alt Symbol	CT80, HILI, PIWIL1L, mili
Species	Human
Gene Type	protein-coding
Description	piwi-like RNA-mediated gene silencing 2
Other Description	80kDa PIWIL2 short isoform|Miwi like|cancer/testis antigen 80|piwi-like 2|piwi-like protein 2|piwil2-like protein
Swissprots	Q96SW6 Q9NW28 B0AZP2 B0AZN9 A8K8S5 Q8TC59 B4DR22 A8K4S3 E7ECA4
Accessions	EAW63686 Q8TC59 AB079367 BAC81342 AK000397 AK001213 BAA91558 AK027497 BAB55155 AK056418 AK291038 BAF83727 AK292440 BAF85129 AK299068 BAG61134 AK315830 BAF98721 AK315833 BAF98724 BC025995 AAH25995 BC111751 AAI11752 DC403636 EU446994 ABZ92523 HQ651229 ADV17663 KF651165 AHF72552 KJ534584 AHZ89834 KM434336 AIY32628 XM_005273550 XP_005273607 XM_005273551 XP_005273608 NM_001135721 NP_001129193 NM_018068 NP_060538
Function	Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate in similar functions during oogenesis in females. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with primary piRNAs in the cytoplasm and is required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense. The pi
Subcellular Location	Cytoplasm {ECO:0000250}. Note=Present in chromatoid body. Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in adult testis and in most tumors. {ECO:0000269|PubMed:16377660}.
Top Pathways	Dorso-ventral axis formation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PIWIL2 (K-18) - sc-67502 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

PIWIL2 (M-240) - sc-67304 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

PIWIL2 (H-80) - sc-67303 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

PIWIL2 (N-20) - sc-67503 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

PIWIL2 (S-18) - sc-67505 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-PIWIL2 antibody - ab181340 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PIWIL2 antibody - ab169698 from Abcam Prices $376.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-PIWIL2 antibody [87/3] - ab151398 from Abcam Prices $359.00 Sizes 200 µl Host Mouse Clonality Monoclonal Clone 87/3

Anti-PIWIL2 antibody - N-terminal - ab138742 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PIWIL2 Antibody (aa287-336) - LS-C107988 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PIWIL2 Antibody (aa216-379) - LS-C184870 from LifeSpan Bioscience Prices $605.00 Sizes 100 µg Host Sheep Clonality Polyclonal

Anti-PIWIL2 Antibody (aa90-119, AP) - LS-C239094 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PIWIL2 Antibody (Internal) - LS-C136919 from LifeSpan Bioscience Prices $255.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PIWIL2 Antibody (C-Terminus) - LS-C137060 from LifeSpan Bioscience Prices $255.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PIWIL2 Antibody - LS-C62097 from LifeSpan Bioscience Prices $305.00 Sizes 100 µl Host Mouse Clonality Monoclonal

Anti-PIWIL2 Antibody (aa90-119, APC) - LS-C239095 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PIWIL2 Antibody (aa90-119, Biotin) - LS-C239096 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PIWIL2 Antibody (aa90-119, FITC) - LS-C239097 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PIWIL2 Antibody (aa90-119, PE) - LS-C239099 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PIWIL2 Antibody (aa90-119, Azide-free, HRP) - LS-C248486 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PIWIL2 Antibody (aa90-119) - LS-C324064 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PIWIL2 Antibody - LS-C341534 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PIWIL2 Antibody (aa90-119) - LS-C158664 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-PIWIL2 Antibody - LS-C179920 from LifeSpan Bioscience Prices $360.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PIWIL2 Antibody (aa30-80) - LS-C148690 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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