PIWIL2

Gene Symbol PIWIL2
Entrez Gene 55124
Alt Symbol CT80, HILI, PIWIL1L, mili
Species Human
Gene Type protein-coding
Description piwi-like RNA-mediated gene silencing 2
Other Description 80kDa PIWIL2 short isoform|Miwi like|cancer/testis antigen 80|piwi-like 2|piwi-like protein 2|piwil2-like protein
Swissprots Q96SW6 Q9NW28 B0AZP2 B0AZN9 A8K8S5 Q8TC59 B4DR22 A8K4S3 E7ECA4
Accessions EAW63686 Q8TC59 AB079367 BAC81342 AK000397 AK001213 BAA91558 AK027497 BAB55155 AK056418 AK291038 BAF83727 AK292440 BAF85129 AK299068 BAG61134 AK315830 BAF98721 AK315833 BAF98724 BC025995 AAH25995 BC111751 AAI11752 DC403636 EU446994 ABZ92523 HQ651229 ADV17663 KF651165 AHF72552 KJ534584 AHZ89834 KM434336 AIY32628 XM_005273550 XP_005273607 XM_005273551 XP_005273608 NM_001135721 NP_001129193 NM_018068 NP_060538
Function Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate in similar functions during oogenesis in females. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with primary piRNAs in the cytoplasm and is required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense. The pi
Subcellular Location Cytoplasm {ECO:0000250}. Note=Present in chromatoid body. Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in adult testis and in most tumors. {ECO:0000269|PubMed:16377660}.
Top Pathways Dorso-ventral axis formation

Mouse PIWIL2 peptide - ab27821 from Abcam

Category Peptide

Mouse PIWIL2 peptide - ab27822 from Abcam

Category Peptide

PIWIL2 Antibody Blocking Peptide - LS-E6352 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

PIWIL2 Antibody Blocking Peptide - LS-E31023 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 50 µg

PIWIL2 Antibody Blocking Peptide - LS-E20826 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

PIWIL2 Antibody Blocking Peptide - LS-E31195 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 50 µg

PIWIL2-Antibody-N-term-Blocking-Peptide - BP19056a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

PIWIL2 Blocking Peptide - 33R-7778 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

PIWIL2 (N-term) Control Peptide - AP55576CP-N from Acris Antibodies

Category Peptide
Prices $135.00
Sizes 50 µg

PIWIL2 (Center) Control Peptide - AP55663CP-N from Acris Antibodies

Category Peptide
Prices $135.00
Sizes 50 µg

PIWIL2 fusion protein - Ag5423 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

Recombinant Human PIWIL2, His-tagged - PIWIL2-1737H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human Piwi-like protein 2(PIWIL2) ,partial - CSB-YP837429HU CSB-EP837429HU CSB-BP837429HU CSB-MP837429HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Piwi-like protein 2 (PIWIL2), partial, Recombinant Protein - MBS1450111 from MyBioSource

Category Protein
Prices $885.00, $885.00, $1,105.00, $1,105.00, $1,235.00, $1,235.00, $1,238.00, $1,695.00, $1,695.00, $2,450.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 500 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 1 mg (Baculovirus)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

PIWIL2 Peptide, Human - M34GP11829H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human
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