PIWIL2

Gene Symbol PIWIL2
Entrez Gene 55124
Alt Symbol CT80, HILI, PIWIL1L, mili
Species Human
Gene Type protein-coding
Description piwi-like RNA-mediated gene silencing 2
Other Description 80kDa PIWIL2 short isoform|Miwi like|cancer/testis antigen 80|piwi-like 2|piwi-like protein 2|piwil2-like protein
Swissprots Q96SW6 Q9NW28 B0AZP2 B0AZN9 A8K8S5 Q8TC59 B4DR22 A8K4S3 E7ECA4
Accessions EAW63686 Q8TC59 AB079367 BAC81342 AK000397 AK001213 BAA91558 AK027497 BAB55155 AK056418 AK291038 BAF83727 AK292440 BAF85129 AK299068 BAG61134 AK315830 BAF98721 AK315833 BAF98724 BC025995 AAH25995 BC111751 AAI11752 DC403636 EU446994 ABZ92523 HQ651229 ADV17663 KF651165 AHF72552 KJ534584 AHZ89834 KM434336 AIY32628 XM_005273550 XP_005273607 XM_005273551 XP_005273608 NM_001135721 NP_001129193 NM_018068 NP_060538
Function Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate in similar functions during oogenesis in females. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with primary piRNAs in the cytoplasm and is required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense. The pi
Subcellular Location Cytoplasm {ECO:0000250}. Note=Present in chromatoid body. Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in adult testis and in most tumors. {ECO:0000269|PubMed:16377660}.
Top Pathways Dorso-ventral axis formation

HILI CRISPR/Cas9 KO Plasmid (h) - sc-402211 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HILI HDR Plasmid (h) - sc-402211-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HILI Double Nickase Plasmid (h) - sc-402211-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HILI Double Nickase Plasmid (h2) - sc-402211-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HILI CRISPR Activation Plasmid (h) - sc-402211-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HILI CRISPR Activation Plasmid (h2) - sc-402211-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HILI Lentiviral Activation Particles (h) - sc-402211-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HILI Lentiviral Activation Particles (h2) - sc-402211-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PIWIL2 siRNA (h) - sc-62456 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PIWIL2 shRNA Plasmid (h) - sc-62456-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PIWIL2 shRNA (h) Lentiviral Particles - sc-62456-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU015071 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16848 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16848 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04994 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04994

PIWIL2 siRNA (Human) - CRJ0486 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PIWI (NM_018068.3) - SHH376272 from Creative biogene

Category siRNA
Species Reactivities Human

PIWIL2 shRNA Plasmid (Human) - CHJ0486 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PIWIL2 miRNA 3'UTR clone - MiUTR3H-11148 from Creative biogene

Species Reactivities Human

PIWIL2 miRNA 3'UTR clone - MiUTR3H-11149 from Creative biogene

Species Reactivities Human
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