PDHA1

Gene Symbol PDHA1
Entrez Gene 5160
Alt Symbol PDHA, PDHAD, PDHCE1A, PHE1A
Species Human
Gene Type protein-coding
Description pyruvate dehydrogenase (lipoamide) alpha 1
Other Description PDHE1-A type I|pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial|pyruvate dehydrogenase complex, E1-alpha polypeptide 1
Swissprots Q53H41 B7Z3T7 A5YVE9 Q9NP12 Q9UBJ8 Q5JPT8 Q9UNG5 Q9UBU0 P08559 Q9UNG4 B7Z3X5 B2R5P7
Accessions AAA31853 AAA60051 AAB32351 AAB39723 AAB39724 AAB39725 AAB39726 AAB39727 AAB39728 AAB39729 AAB39730 AAD16047 AAD23841 AAD23842 AAD23843 AAD23844 AAD23845 AAD23846 AAD23847 AAD23848 AAD23849 AAD23850 AAD23851 AAD23852 AAD23853 AAD23854 AAD23855 AAD23856 AAD23857 AAD23858 AAD23859 AAD23860 AAD23861 AAD23862 AAD23863 AAD23864 AAD23866 AAD23867 AAD23868 AAD23869 AAD23870 AAD23871 AAD23872 AAD23873 AAD23874 AAD23875 AAD23876 BAA14121 EAW98960 EAW98961 P08559 AK129887 AK222740 BAD96460 AK222988 BAD96708 AK293250 BAH11476 AK296341 BAH12323 AK296457 BAH12361 AK312263 BAG35194 AW204705 BC002406 AAH02406 BU170389 DA075402 DC361191 DQ891865 ABM82791 DQ895054 ABM85980 DQ895057 ABM85983 EF576990 ABQ58815 EF590116 EF590117 ABQ59099 J03503 AAA60055 J03575 AAA60050 L13318 AAA60227 L48690 AAB59581 M24848 AAA36533 R49470 S89908 AAB21863 X52709 CAA36933 X52710 CAA36934 XM_011545531 XP_011543833 XM_011545532 XP_011543834 NM_000284 NP_000275 NM_001173454 NP_001166925 NM_001173455 NP_001166926 NM_001173456 NP_001166927
Function The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000269|PubMed:19081061, ECO:0000269|PubMed:7782287}.
Subcellular Location Mitochondrion matrix.
Tissue Specificity Ubiquitous.
Top Pathways Glycolysis / Gluconeogenesis, Citrate cycle (TCA cycle), Central carbon metabolism in cancer, Glucagon signaling pathway, Pyruvate metabolism

PDH E1 alpha protein (PDHA1) ELISA Kit - ab115342 from Abcam

Category ELISA Kit
Sensitivity = 15 ng/ml
Example of standard curve constructed using ab115342.

PDH E1 alpha protein (PDHA1) Human SimpleStep ELISA™Kit - ab181415 from Abcam

Category ELISA Kit
Prices $484.00
Sizes 1 x 96 tests
Sensitivity 12 ng/ml
Range 15.6 ng/ml - 1000 ng/ml
Example of PDH E1 alpha (PDHA1) standard curve. Background-subtracted data values (mean +/- SD) are graphed.

Phospho S232 PDH E1 alpha protein (PDHA1) Profiling ELISA Kit - ab115343 from Abcam

Category ELISA Kit
Prices $448.00
Sizes 1 x 96 tests
Sensitivity = 31 µg/ml
Range 31 µg/ml - 1000 µg/ml
The PDHA1 bound from undosed HeLa cells was subject to in-well kinase treatment (PDK1&3) or in-well phosphatase treatment (PDP1) according to the supplementary protocol shown below. Untreated cells showed a significant endogenous phosphorylation signal at S232 which is only slightly increased by kinase treatment. Conversely phosphatase treatment was able to significantly reduce the phospho S232 signal from the endogenous levels.

Phospho S293 PDH E1 alpha protein (PDHA1) Profiling ELISA Kit - ab115344 from Abcam

Category ELISA Kit
Sensitivity = 63 µg/ml
Range 63 µg/ml - 1000 µg/ml
Example control sample curve. The phosphorylation state of PDHA1 can vary by treatment but also by cell culture conditions such as media supplements, nutrients and also cell density.

Phospho S300 PDH E1 alpha protein (PDHA1) Profiling ELISA Kit - ab115345 from Abcam

Category ELISA Kit
Prices $448.00
Sizes 1 x 96 tests
Sensitivity 15 µg/ml
Range 15 µg/ml - 500 µg/ml
The phosphorylation state of PDHA1 can vary by treatment but also by cell culture conditions such as media supplements, nutrients and also cell density.

Human PDHA1 / PDH E1 Alpha ELISA Kit (Sandwich ELISA) - LS-F4365 from LifeSpan Bioscience

Category ELISA Kit
Prices $650.00
Sizes 1 plate
Sensitivity 0.055 ng/ml
Range 0.156-10 ng/ml

Mouse PDHA1 / PDH E1 Alpha ELISA Kit (Sandwich ELISA) - LS-F4366 from LifeSpan Bioscience

Category ELISA Kit
Prices $670.00
Sizes 1 plate
Sensitivity 34 pg/ml
Range 0.156-10 ng/ml

Rat PDHA1 / PDH E1 Alpha ELISA Kit (Sandwich ELISA) - LS-F5763 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Sensitivity 0.33 ng/ml
Range 0.156-10 ng/ml

Rat PDHA1 / PDH E1 Alpha ELISA Kit (Sandwich ELISA) - LS-F12214 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 0.312
Range 0.156-10 ng/ml

Human PDHa ELISA Kit - abx152684 from Abbexa

Category ELISA Kit
Sensitivity 0.055 ng/ml
Range 0.156 ng/ml - 10 ng/ml

Pyruvate Dehydrogenase Alpha, PDHa, Human, ELISA Kit - E-EL-H1091 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t
Sensitivity 0.094
Range 0.156-10ng/mL

Pyruvate Dehydrogenase Alpha (PDHa), Human, ELISA Kit - SEA776Hu from ARP American Research Products

Category ELISA Kit
Prices $650.00
Sizes 96 t
Sensitivity 0.078 ng/mL
Range 0.156-10 ng/mL

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1), Human, ELISA Kit - E01P0835 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, PDHA1, Human, ELISA Kit - E0776h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t

Pyruvate Dehydrogenase Alpha, PDHa, Mouse, ELISA Kit - E-EL-M0996 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t
Sensitivity 0.094
Range 0.156-10ng/mL

Pyruvate Dehydrogenase Alpha, PDHA, Rat, ELISA Kit - E-EL-R0834 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t
Sensitivity 0.469
Range 0.781-50ng/mL

Pyruvate Dehydrogenase Alpha, PDHa, Rabbit, ELISA Kit - E-EL-RB1859 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Pyruvate Dehydrogenase Alpha, PDHa, Chicken, ELISA Kit - E-EL-Ch0816 from ARP American Research Products

Category ELISA Kit
Prices $504.00
Sizes 96 t

Pyruvate Dehydrogenase Alpha, PDHa, Porcine, ELISA Kit - E-EL-P1481 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Pyruvate Dehydrogenase Alpha, PDHa, Monkey, ELISA Kit - E-EL-MK0824 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Anserine PDHa ELISA Kit - AP0084 from NeoScientific

Category ELISA Kit
Prices $300.00, $480.00
Sizes 100 µl, 200 µl

Pyruvate Dehydrogenase E1, ELISA Kit - MBS732458 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1), ELISA Kit - MBS7201297 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1), ELISA Kit - MBS7238957 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1), ELISA Kit - MBS7208530 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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