NLRP2

Gene Symbol NLRP2
Entrez Gene 55655
Alt Symbol CLR19.9, NALP2, NBS1, PAN1, PYPAF2
Species Human
Gene Type protein-coding
Description NLR family, pyrin domain containing 2
Other Description NACHT, LRR and PYD containing protein 2|NACHT, LRR and PYD domains-containing protein 2|NACHT, leucine rich repeat and PYD containing 2|PYRIN domain and NACHT domain-containing protein 1|PYRIN-containing APAF1-like protein 2|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2|nucleotide-binding site protein 1
Swissprots Q9NX02 B4DZL7 Q59G09 Q53FL5 Q9HAV9 Q9BVN5 Q8IXT0 Q9NWK3 Q9H6G6 I3L0G4
Accessions EAW72317 EAW72318 EAW72319 EAW72320 Q9NX02 AB209300 BAD92537 AF269288 AAG23171 AF298547 AAG15253 AF310106 AAG30289 AF464764 AAL69962 AK000517 BAA91223 AK000784 BAA91377 AK025952 BAB15293 AK223253 BAD96973 AK223269 BAD96989 AK292681 BAF85370 AK302989 BAG64129 BC001039 AAH01039 BC003592 AAH03592 BC039269 AAH39269 DA856893 DB046128 DQ895069 ABM85995 EU176313 ABW03764 NM_001174081 NP_001167552 NM_001174082 NP_001167553 NM_001174083 NP_001167554 NM_017852 NP_060322
Function Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. {ECO:0000269|PubMed:15456791}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15030775, ECO:0000269|PubMed:15456791}.
Tissue Specificity Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain. {ECO:0000269|PubMed:15456791}.

NALP2 (E-5) - sc-365935 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NALP2 (E-5): sc-365935. Western blot analysis of NALP2 expression in K-562 whole cell lysate.

NALP2 (H-4) - sc-166584 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NALP2 (H-4): sc-166584. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

NALP2 (H-87) - sc-292716 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NALP2 (H-87): sc-292716. Western blot analysis of NALP2 expression in K-562 whole cell lysate.

NALP2 (E-20) - sc-50616 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NALP2 (E-20): sc-50616. Western blot analysis of NALP2 expression in MCF7 (A), K-562 (B), NK-92 (C) and HeLa (D) whole cell lysates.

NALP2 (K-18) - sc-50617 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NALP2 (K-18): sc-50617. Western blot analysis of NALP2 expression in K-562 whole cell lysate.

NALP2 (S-20) - sc-50619 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NALP2 (S-20): sc-50619. Western blot analysis of NALP2 expression in K-562 whole cell lysate.

Anti-NALP2 antibody - ab36850 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-NALP2 antibody (ab36850) at 1 µg/ml + PC-3 cell lysate

Anti-NALP2 antibody - ab137569 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-NALP2 antibody (ab137569) at 1/10000 dilution + A431 whole cell lysate at 30 µg

Anti-NALP2 antibody - ab115614 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab115614, at 5µg/ml, staining NLRP2 in Formalin-fixed, Paraffin-embedded Human brain cortex tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-NALP2 antibody - ab103922 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-NALP2 antibody (ab103922) at 0.5 µg/ml + K562 lysate in RIPA buffer at 35 µgdeveloped using the ECL technique

Anti-NALP2 antibody - ab118394 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Lane 1 : Anti-NALP2 antibody (ab118394) at 1 µg/ml (incubation time: 1 hour)Lane 2 : Anti-NALP2 antibody (ab118394) at 1 mg/ml (incubation time: 1 hour)Lane 1 : lysate from HEK293 cells transiently transfected with a vector overexpressing NALP2Lane 2 : lysate from mock transfected HEK293 cellsLysates/proteins at 10 µg per lane.developed using the ECL technique

Anti-NALP2 antibody - ab168136 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-NALP2 antibody (ab168136) at 1 µg/mlLane 1 : NALP2 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-NLRP2 / NALP2 Antibody (C-Terminus) IHC-plus™ - LS-B529 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-NALP2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B529 concentration 5 ug/ml.

Anti-NLRP2 / NALP2 Antibody - LS-C9213 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NLRP2 / NALP2 Antibody (aa1-208) - LS-C73139 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-NLRP2 / NALP2 Antibody (aa1-208) - LS-C130967 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-NLRP2 / NALP2 Antibody (aa1037-1050) - LS-C112984 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
NLRP2 antibody (0.5 ug/ml) staining of K562 lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-NLRP2 / NALP2 Antibody (aa144-159) - LS-C148283 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Western blot of NALP2 (PAN1/PYPAF2) in differentiated THP-1 cells following IFN (interferon)

Anti-NLRP2 / NALP2 Antibody (aa130-180) - LS-C148524 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of NALP2 in LNCAP cell lysate in the 1) absence and 2) presence of immunizing peptide using LS-C148524 at 0.25 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.

Anti-NLRP2 / NALP2 Antibody (C-Terminus) - LS-C135422 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
NLRP2 / NALP2 antibody LS-C135422 Western blot of COLO205 cell lysate.

Anti-NBN / Nibrin Antibody (Gly274) - LS-C176995 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of NBS1 (G274) pAb in extracts from Jurkat cells.

Anti-NLRP2 / NALP2 Antibody (aa1030-1080) - LS-C148535 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of NALP2 in formalin-fixed, paraffin-embedded human colon tumor tissue using an isotype control (top left) and LS-C148535 (bottom left, right) at 5 ug/ml.

Anti-NLRP2 / NALP2 Antibody (aa97-115) - LS-C148284 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Western blot of NALP2 using NALP2 antibody at 1:2000. HEK293T: mock transfected cells, HEK293T-NALP2: NALP2 transiently transfected cells; THP-1: untreated cells; THP1-LPS: cells treated with 1 ug/ml LPS for 4h. MCF-7: untreated cells.

NLRP2/NALP2 Antibody - NB100-56155 from Novus Biologicals

Prices $129.00, $199.00
Sizes 25 µl, 50 µl
Host Rabbit
Clonality Polyclonal

NLRP2/NALP2 Antibody - NB100-56154 from Novus Biologicals

Prices $229.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Western Blot: NALP2 Antibody [NB100-56154] - Analysis of NALP2 (PAN1/PYPAF2) in differentiated THP-1 cells following IFN (interferon) stimulation using NALP2 antibody at 1:2000. TPA-differentiated THP-1 cells were cultured with 1000 units of IFNg for 0-24 hours as described in Bruey et al, 2004. Culturing differentiated THP-1 with IFNg resulted in transient elevations in NALP2 expression which peaked at 4-8 h after INFg treatment.
Search more