NLRP2

Gene Symbol NLRP2
Entrez Gene 55655
Alt Symbol CLR19.9, NALP2, NBS1, PAN1, PYPAF2
Species Human
Gene Type protein-coding
Description NLR family, pyrin domain containing 2
Other Description NACHT, LRR and PYD containing protein 2|NACHT, LRR and PYD domains-containing protein 2|NACHT, leucine rich repeat and PYD containing 2|PYRIN domain and NACHT domain-containing protein 1|PYRIN-containing APAF1-like protein 2|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2|nucleotide-binding site protein 1
Swissprots Q9NX02 B4DZL7 Q59G09 Q53FL5 Q9HAV9 Q9BVN5 Q8IXT0 Q9NWK3 Q9H6G6 I3L0G4
Accessions EAW72317 EAW72318 EAW72319 EAW72320 Q9NX02 AB209300 BAD92537 AF269288 AAG23171 AF298547 AAG15253 AF310106 AAG30289 AF464764 AAL69962 AK000517 BAA91223 AK000784 BAA91377 AK025952 BAB15293 AK223253 BAD96973 AK223269 BAD96989 AK292681 BAF85370 AK302989 BAG64129 BC001039 AAH01039 BC003592 AAH03592 BC039269 AAH39269 DA856893 DB046128 DQ895069 ABM85995 EU176313 ABW03764 NM_001174081 NP_001167552 NM_001174082 NP_001167553 NM_001174083 NP_001167554 NM_017852 NP_060322
Function Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. {ECO:0000269|PubMed:15456791}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15030775, ECO:0000269|PubMed:15456791}.
Tissue Specificity Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain. {ECO:0000269|PubMed:15456791}.

NALP2 CRISPR/Cas9 KO Plasmid (h) - sc-412564 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NALP2 HDR Plasmid (h) - sc-412564-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NALP2 Double Nickase Plasmid (h) - sc-412564-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NALP2 Double Nickase Plasmid (h2) - sc-412564-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NALP2 CRISPR Activation Plasmid (h) - sc-412564-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NALP2 CRISPR Activation Plasmid (h2) - sc-412564-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NALP2 Lentiviral Activation Particles (h) - sc-412564-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NALP2 Lentiviral Activation Particles (h2) - sc-412564-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NALP2 siRNA (h) - sc-61143 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NALP2 shRNA Plasmid (h) - sc-61143-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NALP2 shRNA (h) Lentiviral Particles - sc-61143-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU086731 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15354 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15354 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01350 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01350

NLRP2 siRNA (Human) - CRJ0807 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NLRP2 (NM_017852.3) - SHH352956 from Creative biogene

Category siRNA
Species Reactivities Human

Human NLRP2 siRNA - orb271308 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NLRP2 shRNA Plasmid (Human) - CHJ0807 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NLRP2 miRNA 3'UTR clone - MiUTR3H-10560 from Creative biogene

Species Reactivities Human
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