| Gene Symbol |
NLRP2
|
| Entrez Gene |
55655
|
| Alt Symbol |
CLR19.9, NALP2, NBS1, PAN1, PYPAF2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NLR family, pyrin domain containing 2
|
| Other Description |
NACHT, LRR and PYD containing protein 2|NACHT, LRR and PYD domains-containing protein 2|NACHT, leucine rich repeat and PYD containing 2|PYRIN domain and NACHT domain-containing protein 1|PYRIN-containing APAF1-like protein 2|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2|nucleotide-binding site protein 1
|
| Swissprots |
Q9NX02 B4DZL7 Q59G09 Q53FL5 Q9HAV9 Q9BVN5 Q8IXT0 Q9NWK3 Q9H6G6 I3L0G4
|
| Accessions |
EAW72317 EAW72318 EAW72319 EAW72320 Q9NX02 AB209300 BAD92537 AF269288 AAG23171 AF298547 AAG15253 AF310106 AAG30289 AF464764 AAL69962 AK000517 BAA91223 AK000784 BAA91377 AK025952 BAB15293 AK223253 BAD96973 AK223269 BAD96989 AK292681 BAF85370 AK302989 BAG64129 BC001039 AAH01039 BC003592 AAH03592 BC039269 AAH39269 DA856893 DB046128 DQ895069 ABM85995 EU176313 ABW03764 NM_001174081 NP_001167552 NM_001174082 NP_001167553 NM_001174083 NP_001167554 NM_017852 NP_060322
|
| Function |
Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. {ECO:0000269|PubMed:15456791}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15030775, ECO:0000269|PubMed:15456791}.
|
| Tissue Specificity |
Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain. {ECO:0000269|PubMed:15456791}.
|