| Gene Symbol | ATF1 |
|---|---|
| Entrez Gene | 466 |
| Alt Symbol | EWS-ATF1, FUS/ATF-1, TREB36 |
| Species | Human |
| Gene Type | protein-coding |
| Description | activating transcription factor 1 |
| Other Description | cAMP-dependent transcription factor ATF-1|cyclic AMP-dependent transcription factor ATF-1 |
| Swissprots | P25168 P18846 B4DRF9 |
| Accessions | AAB25878 CAA39150 EAW58151 P18846 AK299240 BAG61271 AK313406 BAG36201 BC029619 AAH29619 BG502726 BG545632 BG611151 BG611861 BI712653 BU682151 BX102171 DA468394 EU446464 ABZ91993 EU446626 ABZ92155 XM_011538386 XP_011536688 XM_011538387 XP_011536689 XM_011538388 XP_011536690 NM_005171 NP_005162 |
| Function | This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. {ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:20980392}. |
| Subcellular Location | Nucleus. |
| Top Pathways | HTLV-I infection, Transcriptional misregulation in cancer |