Gene Symbol |
ATF1
|
Entrez Gene |
466
|
Alt Symbol |
EWS-ATF1, FUS/ATF-1, TREB36
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
activating transcription factor 1
|
Other Description |
cAMP-dependent transcription factor ATF-1|cyclic AMP-dependent transcription factor ATF-1
|
Swissprots |
P25168 P18846 B4DRF9
|
Accessions |
AAB25878 CAA39150 EAW58151 P18846 AK299240 BAG61271 AK313406 BAG36201 BC029619 AAH29619 BG502726 BG545632 BG611151 BG611861 BI712653 BU682151 BX102171 DA468394 EU446464 ABZ91993 EU446626 ABZ92155 XM_011538386 XP_011536688 XM_011538387 XP_011536689 XM_011538388 XP_011536690 NM_005171 NP_005162
|
Function |
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. {ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:20980392}.
|
Subcellular Location |
Nucleus.
|
Top Pathways |
HTLV-I infection, Transcriptional misregulation in cancer
|