Gene Symbol | ATF1 |
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Entrez Gene | 466 |
Alt Symbol | EWS-ATF1, FUS/ATF-1, TREB36 |
Species | Human |
Gene Type | protein-coding |
Description | activating transcription factor 1 |
Other Description | cAMP-dependent transcription factor ATF-1|cyclic AMP-dependent transcription factor ATF-1 |
Swissprots | P25168 P18846 B4DRF9 |
Accessions | AAB25878 CAA39150 EAW58151 P18846 AK299240 BAG61271 AK313406 BAG36201 BC029619 AAH29619 BG502726 BG545632 BG611151 BG611861 BI712653 BU682151 BX102171 DA468394 EU446464 ABZ91993 EU446626 ABZ92155 XM_011538386 XP_011536688 XM_011538387 XP_011536689 XM_011538388 XP_011536690 NM_005171 NP_005162 |
Function | This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. {ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:20980392}. |
Subcellular Location | Nucleus. |
Top Pathways | HTLV-I infection, Transcriptional misregulation in cancer |
ATF-1 CRISPR/Cas9 KO Plasmid (h) - sc-400488 from Santa Cruz Biotechnology
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ATF-1 HDR Plasmid (h) - sc-400488-HDR from Santa Cruz Biotechnology
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ATF-1 Double Nickase Plasmid (h) - sc-400488-NIC from Santa Cruz Biotechnology
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ATF-1 Double Nickase Plasmid (h2) - sc-400488-NIC-2 from Santa Cruz Biotechnology
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ATF-1 CRISPR Activation Plasmid (h) - sc-400488-ACT from Santa Cruz Biotechnology
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ATF-1 CRISPR Activation Plasmid (h2) - sc-400488-ACT-2 from Santa Cruz Biotechnology
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ATF-1 Lentiviral Activation Particles (h) - sc-400488-LAC from Santa Cruz Biotechnology
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ATF-1 Lentiviral Activation Particles (h2) - sc-400488-LAC-2 from Santa Cruz Biotechnology
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ATF-1 siRNA (h) - sc-29754 from Santa Cruz Biotechnology
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ATF-1 shRNA Plasmid (h) - sc-29754-SH from Santa Cruz Biotechnology
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ATF-1 shRNA (h) Lentiviral Particles - sc-29754-V from Santa Cruz Biotechnology
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ATF1 RNAi - H00000466-R01V from Novus Biologicals
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ATF1 RNAi - H00000466-R01 from Novus Biologicals
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MISSION® esiRNA - EHU006361 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3633 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3633 from Sigma-Aldrich
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ATF1 siRNA (Human) - CRH0324 from Cohesion Biosciences
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ATF1 - MBS8239827 from MyBioSource
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shRNA set against Human ATF1 (NM_005171.4) - SHH241894 from Creative biogene
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ATF1 shRNA Plasmid (Human) - CHH0324 from Cohesion Biosciences
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ATF1 miRNA 3'UTR clone - MiUTR3H-00558 from Creative biogene
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