| Gene Symbol |
MYO1G
|
| Entrez Gene |
64005
|
| Alt Symbol |
HA2, HLA-HA2, MHAG
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
myosin IG
|
| Other Description |
minor histocompatibility antigen HA-2|myosin-Ig|unconventional myosin-Ig
|
| Swissprots |
Q96RI5 Q96BE2 Q96RI6 Q8TES2 Q8TEI9 B0I1T2
|
| Accessions |
B0I1T2 EAL23748 EAW61068 EAW61069 EAW61070 EAW61071 EAW61072 AA651942 AB290179 BAG06733 AF380932 AAK58092 AF380933 AAK58093 AK074050 BAB84876 AK074135 BAB84961 AK097912 BAG53548 AK131089 BAC85139 AL832302 BC007370 BC015693 AAH15693 BC031337 BC041623 BC063854 BC113544 AAI13545 BC117241 AAI17242 BI910371 DB131347 XR_926942 XR_926943 NM_033054 NP_149043
|
| Function |
Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T- cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B- cells, where it regulates different membrane/cytoskeleton- dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. {ECO:0000250|UniProtKB:Q5SUA5}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:19968988, ECO:0000269|PubMed:20071333}; Peripheral membrane protein {ECO:0000269|PubMed:19968988, ECO:0000269|PubMed:20071333}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q5SUA5}. Note=Recruited to Fc-gamma receptor (Fc-gamma-R) phagocytic cup. In T-cells, transiently accumulates in discrete areas at the plasma membrane of migrating cells or when membranes are deformed (By similarity). Localization at the membrane is not highly dependent on phosphatidylinositol 4,5-bisphosphate levels. Released from the membrane in the presence of ATP. May be enriched in peripheral processes, such as microvilli or ruffles. {ECO:0000250|UniProtKB:Q5SUA5, ECO:0000269|PubMed:20071333}.
|
| Tissue Specificity |
Specifically expressed in hematopoietic cells. {ECO:0000269|PubMed:11544309, ECO:0000269|PubMed:20071333}.
|