MYO1G

Gene Symbol MYO1G
Entrez Gene 64005
Alt Symbol HA2, HLA-HA2, MHAG
Species Human
Gene Type protein-coding
Description myosin IG
Other Description minor histocompatibility antigen HA-2|myosin-Ig|unconventional myosin-Ig
Swissprots Q96RI5 Q96BE2 Q96RI6 Q8TES2 Q8TEI9 B0I1T2
Accessions B0I1T2 EAL23748 EAW61068 EAW61069 EAW61070 EAW61071 EAW61072 AA651942 AB290179 BAG06733 AF380932 AAK58092 AF380933 AAK58093 AK074050 BAB84876 AK074135 BAB84961 AK097912 BAG53548 AK131089 BAC85139 AL832302 BC007370 BC015693 AAH15693 BC031337 BC041623 BC063854 BC113544 AAI13545 BC117241 AAI17242 BI910371 DB131347 XR_926942 XR_926943 NM_033054 NP_149043
Function Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T- cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B- cells, where it regulates different membrane/cytoskeleton- dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis. {ECO:0000250|UniProtKB:Q5SUA5}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:19968988, ECO:0000269|PubMed:20071333}; Peripheral membrane protein {ECO:0000269|PubMed:19968988, ECO:0000269|PubMed:20071333}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q5SUA5}. Note=Recruited to Fc-gamma receptor (Fc-gamma-R) phagocytic cup. In T-cells, transiently accumulates in discrete areas at the plasma membrane of migrating cells or when membranes are deformed (By similarity). Localization at the membrane is not highly dependent on phosphatidylinositol 4,5-bisphosphate levels. Released from the membrane in the presence of ATP. May be enriched in peripheral processes, such as microvilli or ruffles. {ECO:0000250|UniProtKB:Q5SUA5, ECO:0000269|PubMed:20071333}.
Tissue Specificity Specifically expressed in hematopoietic cells. {ECO:0000269|PubMed:11544309, ECO:0000269|PubMed:20071333}.

Myosin Ig (H-60) - sc-66987 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Myosin Ig (N-18) - sc-32714 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Myosin 1G antibody - ab121657 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent staining of Human cell line U-2 OS shows positivity in nucleus but not nucleoli. Recommended concentration of ab121657 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Anti-MYO1G / HA2 Antibody (aa769-1016, Biotin) - LS-C298680 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MYO1G / HA2 Antibody (aa769-1016, FITC) - LS-C305367 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MYO1G / HA2 Antibody (Internal) - LS-C60096 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Myosin 1G Antibody - Western Blot. Western blot of affinity purified anti-Myosin 1G antibody shows detection of a band ~100 kD in size corresponding to Myosin 1G (arrowhead) in Myosin 1G positive whole cell lysate - lane 1 Jurkat, lane 2 peripheral blood T cells, lane 3 human spleen and lane 4 300.19. Lane 5, 293 cells, appear negative for Myosin 1G. Personal Communication. Stephen Shaw, NCI, Bethesda, MD.

Anti-MYO1G / HA2 Antibody (aa769-1016) - LS-C295505 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant MYO1G / HA2.

MYO1G Antibody - NBP1-93704 from Novus Biologicals

Prices $129.00, $419.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: MYO1G Antibody [NBP1-93704] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10Lane 2: Human cell line MOLT-4

Anti-MYO1G antibody produced in rabbit - HPA021252 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MYO1G: <B>Cat. No. HPA021252</B>: Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in lymphoid cells outside reaction centra.

HA antibody - 10R-10452 from Fitzgerald

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone M78821

Myosin IG Antibody - abx100607 from Abbexa

Host Rabbit
Clonality Polyclonal

Myosin-Ig antibody - PAB10281 from Acris Antibodies

Prices $580.00
Sizes 100 µg
Clonality Polyclonal
Western blot using MYO1G polyclonal antibody ( Cat # PAB10281 ) shows detection of a band ~100 kDa in size corresponding to MYO1G ( arrowhead ) in MYO1G positive whole cell lysate. Lane 1 Jurkat, lane 2 peripheral blood T cells, lane 3 human spleen and lane 4 300.19. Lane 5, 293 cells, appear negative for MYO1G. Personal Communication. Stephen Shaw, NCI, Bethesda, MD.

Anti-Myosin IG (MYO1G) - 20-4887 from ARP American Research Products

Prices $339.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-Myosin 1G Antibody - GWB-D67AC0 from Genway Biotech

Prices $500.00
Sizes 100 μg
Host Rabbit

Anti-MYO1G (aa 271-356) polyclonal antibody - DPABH-19685 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Polyclonal Antibody to Myosin IG (MYO1G) - PAD436Hu01 from Uscn Life Science Inc.

Host Rabbit
Clonality Polyclonal

Biotin-Linked Antibody to Myosin IG (MYO1G) - PAD436Hu71 from Uscn Life Science Inc.

Host Rabbit
Clonality Polyclonal

Polyclonal Antibody to Myosin IG (MYO1G) - PAD436Mu01 from Uscn Life Science Inc.

Host Rabbit
Clonality Polyclonal

Polyclonal Antibody to Myosin IG (MYO1G) - PAD436Ra01 from Uscn Life Science Inc.

Host Rabbit
Clonality Polyclonal

HA2 (A/Vietnam/1203/2004)(H5N1), Polyclonal Antibody - MBS432030 from MyBioSource

Prices $340.00
Sizes 100 µg
Clonality Polyclonal

Myosin IG (MYO1G), Polyclonal Antibody - MBS2007835 from MyBioSource

Prices $390.00
Sizes 100 µg
Clonality Polyclonal

Myosin IG (MYO1G), Polyclonal Antibody - MBS2014282 from MyBioSource

Prices $425.00
Sizes 100 µg
Clonality Polyclonal

Myosin IG (MYO1G), Polyclonal Antibody - MBS2006934 from MyBioSource

Prices $160.00, $320.00, $495.00
Sizes 20 µg, 100 µg, 200 µg
Host Rabbit
Clonality Polyclonal

HA2 (B/Tokyo/53/99), Monoclonal Antibody - MBS430055 from MyBioSource

Prices $325.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone H18

Myosin 1G Antibody - 600-401-959 from Rockland Immunochemicals Inc

Prices $319.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot using Rockland's affinity purified anti-Myosin 1G antibody shows detection of a band ~100 kDa in size corresponding to Myosin 1G (arrowhead) in Myosin 1G positive whole cell lysate - lane 1 Jurkat, lane 2 peripheral blood T cells, lane 3 human spleen and lane 4 300.19. Lane 5, 293 cells, appear negative for Myosin 1G. Personal Communication. Stephen Shaw, NCI, Bethesda, MD.
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