| Gene Symbol |
ZRSR2
|
| Entrez Gene |
8233
|
| Alt Symbol |
U2AF1-RS2, U2AF1L2, U2AF1RS2, URP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2
|
| Other Description |
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2|U2 small nuclear ribonucleoprotein auxiliary factor, small subunit 2|U2(RNU2) small nuclear RNA auxiliary factor 1-like 2|U2AF35-related protein|renal carcinoma antigen NY-REN-20
|
| Swissprots |
Q14D69 Q15696
|
| Accessions |
EAW98900 EAW98901 EAW98902 Q15696 AK090845 AK309673 BC050451 AAH50451 BC065719 BC113454 AAI13455 BC113480 AAI13481 D49677 BAA08533 HQ258575 ADR83329 XM_005274597 XP_005274654 XM_006724519 XP_006724582 XM_011545589 XP_011543891 XM_011545590 XP_011543892 NM_005089 NP_005080
|
| Function |
Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP- dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. {ECO:0000269|PubMed:21041408, ECO:0000269|PubMed:9237760}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15146077}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:9237760}.
|