Gene Symbol | ZRSR2 |
---|---|
Entrez Gene | 8233 |
Alt Symbol | U2AF1-RS2, U2AF1L2, U2AF1RS2, URP |
Species | Human |
Gene Type | protein-coding |
Description | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 |
Other Description | U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2|U2 small nuclear ribonucleoprotein auxiliary factor, small subunit 2|U2(RNU2) small nuclear RNA auxiliary factor 1-like 2|U2AF35-related protein|renal carcinoma antigen NY-REN-20 |
Swissprots | Q14D69 Q15696 |
Accessions | EAW98900 EAW98901 EAW98902 Q15696 AK090845 AK309673 BC050451 AAH50451 BC065719 BC113454 AAI13455 BC113480 AAI13481 D49677 BAA08533 HQ258575 ADR83329 XM_005274597 XP_005274654 XM_006724519 XP_006724582 XM_011545589 XP_011543891 XM_011545590 XP_011543892 NM_005089 NP_005080 |
Function | Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP- dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. {ECO:0000269|PubMed:21041408, ECO:0000269|PubMed:9237760}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:15146077}. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:9237760}. |
ZRSR2 CRISPR/Cas9 KO Plasmid (h) - sc-406269 from Santa Cruz Biotechnology
|
||||||||
ZRSR2 HDR Plasmid (h) - sc-406269-HDR from Santa Cruz Biotechnology
|
||||||||
ZRSR2 Double Nickase Plasmid (h) - sc-406269-NIC from Santa Cruz Biotechnology
|
||||||||
ZRSR2 Double Nickase Plasmid (h2) - sc-406269-NIC-2 from Santa Cruz Biotechnology
|
||||||||
ZRSR2 CRISPR Activation Plasmid (h) - sc-406269-ACT from Santa Cruz Biotechnology
|
||||||||
ZRSR2 CRISPR Activation Plasmid (h2) - sc-406269-ACT-2 from Santa Cruz Biotechnology
|
||||||||
ZRSR2 Lentiviral Activation Particles (h) - sc-406269-LAC from Santa Cruz Biotechnology
|
||||||||
ZRSR2 Lentiviral Activation Particles (h2) - sc-406269-LAC-2 from Santa Cruz Biotechnology
|
||||||||
ZRSR2 siRNA (h) - sc-90951 from Santa Cruz Biotechnology
|
||||||||
ZRSR2 shRNA Plasmid (h) - sc-90951-SH from Santa Cruz Biotechnology
|
||||||||
ZRSR2 shRNA (h) Lentiviral Particles - sc-90951-V from Santa Cruz Biotechnology
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN23797 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23797 from Sigma-Aldrich
|
||||||||
ZRSR2 siRNA (Human) - CRH5408 from Cohesion Biosciences
|
||||||||
ZRSR2 - MBS8201375 from MyBioSource
|
||||||||
shRNA set against Human ZRSR2 (NM_005089.3) - SHH455848 from Creative biogene
|
||||||||
Human ZRSR2 siRNA - orb265910 from Biorbyt
|
||||||||
ZRSR2 shRNA Plasmid (Human) - CHH5408 from Cohesion Biosciences
|
||||||||
ZRSR2 miRNA 3'UTR clone - MiUTR1H-11758 from Creative biogene
|