BRIP1

Gene Symbol BRIP1
Entrez Gene 83990
Alt Symbol BACH1, FANCJ, OF
Species Human
Gene Type protein-coding
Description BRCA1 interacting protein C-terminal helicase 1
Other Description ATP-dependent RNA helicase BRIP1|BRCA1-associated C-terminal helicase 1|BRCA1-binding helicase-like protein BACH1|BRCA1/BRCA2-associated helicase 1|Fanconi anemia group J protein
Swissprots Q8NCI5 Q9BX63 Q3MJE2
Accessions EAW51430 EAW51431 EAW51432 EAW51433 Q9BX63 AF360549 AAK38111 AK074713 BAC11156 BC101472 AAI01473 BC101474 AAI01475 HQ258538 ADR83292 XM_011525332 XP_011523634 XM_011525333 XP_011523635 XM_011525334 XP_011523636 XM_011525335 XP_011523637 XM_011525336 XP_011523638 XM_011525337 XP_011523639 XM_011525338 XP_011523640 XM_011525339 XP_011523641 XM_011525340 XP_011523642 XM_011525341 XP_011523643 NM_032043 NP_114432
Function DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896}.
Subcellular Location Nucleus {ECO:0000269|PubMed:11301010}.
Tissue Specificity Ubiquitously expressed, with highest levels in testis. {ECO:0000269|PubMed:11301010}.
Top Pathways Fanconi anemia pathway

Phospho-BACH1/BRIP1 (Thr1133) Antibody - 11983 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Jurkat cells, untreated (-) or treated with λ phosphatase and calf intestinal phosphatase (CIP) (+), using Phospho-BACH1/BRIP1 (Thr1133) Antibody (upper) or BACH1/BRIP1 Antibody #4578 (lower).

BACH1/BRIP1 Antibody - 4578 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from SH-SY5Y, Saos-2 and Jurkat cells using BACH1/BRIP1 Antibody.

BRIP1 (E-11) - sc-365708 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
BRIP1 (E-11): sc-365708. Western blot analysis of BRIP1 expression in mouse testis tissue extract.

BRIP1 (L-20) - sc-22540 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
BRIP1 (L-20): sc-22540. Western blot analysis of BRIP1 expression in K-562 whole cell lysate (A) and HeLa nuclear extract (B).

BRIP1 (H-45) - sc-98943 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
BRIP1 (H-45): sc-98943. Western blot analysis of BRIP1 expression in mouse bladder tissue extract.

p-BRIP1 (Ser 990) - sc-32841 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of BRIP1 phosphorylation in untreated (A), calyculin A treated (B) and calyculin A and lambda protein phosphatase (sc-200312A) treated (C) SH-SY5Y whole cell lysates. Antibodies tested include p-BRIP1 (Ser 990): sc-32841 (A,B,C).

Anti-BACH1/BRIP1 antibody - ab49657 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-BACH1/BRIP1 antibody - ab7288 from Abcam

Prices $380.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-BACH1/BRIP1 antibody (ab7288) at 1/1000 dilutionLane 1 : recombinant FLAG-tagged human BACH1Lane 2 : IMR90 cell lysateLane 3 : 293 cell lysateLane 4 : MC7 cell lysate

Anti-BACH1/BRIP1 antibody - ab3502 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-BACH1/BRIP1 antibody (ab3502) at 1/1000 dilutionLane 1 : 293 whole cell lysateLane 2 : 293 whole cell lysate with peptide immunogenLysates/proteins at 35 µg per lane.SecondaryIRDye 800 conjugated Goat-anti-Rabbit IgG [H&L] at 1/10000 dilutionPerformed under reducing conditions.

Anti-BACH1/BRIP1 antibody [3G11] - ab14383 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3G11

Anti-BACH1/BRIP1 antibody [EPR7914(2)] - ab180853 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7914(2)
All lanes : Anti-BACH1/BRIP1 antibody [EPR7914(2)] (ab180853) at 1/1000 dilutionLane 1 : HEK293T cell lysateLane 2 : HeLa cell lysateLane 3 : Jurkat cell lysateLysates/proteins at 10 µg per lane.

Anti-BACH1/BRIP1 antibody - N-terminal - ab151509 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-BACH1/BRIP1 antibody - N-terminal (ab151509) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

Anti-BRIP1 / BACH1 Antibody (clone 2091C2a) - LS-C342424 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2091C2a
Western blot analysis of immunized recombinant protein, using anti-BRIP1 monoclonal antibody.

Anti-BRIP1 / BACH1 Antibody (aa1233-1249) IHC-plus™ - LS-B5084 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-BRIP1 / FANCJ antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5084 concentration 10 ug/ml.

Anti-BRIP1 / BACH1 Antibody (clone pp15-IB4) IHC-plus™ - LS-B74 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone pp15-IB4
Anti-BRIP1 / FANCJ antibody IHC of human spleen, periarteriolar lymphoid sheath. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B74 concentration 10 ug/ml.

Anti-BRIP1 / BACH1 Antibody (aa132-163) - LS-C156861 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
BRIP1 Antibody western blot of mouse bladder tissue lysates (35 ug/lane). The BRIP1 antibody detected the BRIP1 protein (arrow).

Anti-BRIP1 / BACH1 Antibody (clone GO11-3E6) IHC-plus™ - LS-B165 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone GO11-3E6
Anti-BRIP1 / FANCJ antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B165 dilution 1:50.

Anti-BRIP1 / BACH1 Antibody (aa132-163, FITC) - LS-C252701 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BRIP1 / BACH1 Antibody - LS-C20831 from LifeSpan Bioscience

Prices $455.00
Sizes 500 µg
Host Chicken
Clonality Polyclonal

Anti-BRIP1 / BACH1 Antibody (C-Terminus) - LS-C20830 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-BRIP1 / BACH1 Antibody - LS-C65900 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-BRIP1 / BACH1 Antibody - LS-C65901 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-BRIP1 / BACH1 Antibody - LS-C65902 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-BRIP1 / BACH1 Antibody (C-Terminus) - LS-C77236 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-BRIP1 / BACH1 Antibody (aa92-104) - LS-C121793 from LifeSpan Bioscience

Prices $695.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
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