Gene Symbol | CLDN10 |
---|---|
Entrez Gene | 9071 |
Alt Symbol | CPETRL3, OSP-L |
Species | Human |
Gene Type | protein-coding |
Description | claudin 10 |
Other Description | OSP-like protein|claudin-10 |
Swissprots | Q96N78 Q6IBF9 P78369 |
Accessions | EAX08955 P78369 AF339794 AK055855 BAB71030 AK315737 BAG38092 BC010920 AAH10920 BG697724 BU930613 CR456845 CAG33126 DA133712 DA636757 DB544708 DQ892831 ABM83757 DQ896077 ABM87076 U89916 AAC79506 XM_011521134 XP_011519436 NM_001160100 NP_001153572 NM_006984 NP_008915 NM_182848 NP_878268 |
Function | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. May form permselective paracellular pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. Plays a key role in controlling cation selectivity and transport in the thick ascending limb (TAL) of Henle's loop in kidney. {ECO:0000269|PubMed:19383724}. |
Subcellular Location | Cell junction, tight junction {ECO:0000269|PubMed:19383724}. Cell membrane {ECO:0000269|PubMed:19383724}; Multi-pass membrane protein {ECO:0000269|PubMed:19383724}. |
Top Pathways | Tight junction, Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Hepatitis C |