Gene Symbol | GZMH |
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Entrez Gene | 2999 |
Alt Symbol | CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2 |
Species | Human |
Gene Type | protein-coding |
Description | granzyme H (cathepsin G-like 2, protein h-CCPX) |
Other Description | cytotoxic T-lymphocyte proteinase|cytotoxic T-lymphocyte-associated serine esterase 1|cytotoxin serine protease-C|granzyme H |
Swissprots | G3V2C5 Q6XGZ0 Q6XGZ1 P20718 |
Accessions | AAA03514 AAA74885 AAA76859 EAW66004 EAW66005 P20718 AW204493 AY232657 AAP70247 AY232658 AAP70248 BC027974 AAH27974 BQ054303 CD000418 DQ892068 ABM82994 DQ895261 ABM86187 M36118 AAA03248 XM_011536683 XP_011534985 NM_001270780 NP_001257709 NM_001270781 NP_001257710 NM_033423 NP_219491 |
Function | Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication. {ECO:0000269|PubMed:22156497, ECO:0000269|PubMed:23269243}. |
Subcellular Location | Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes. |
Tissue Specificity | Constituvely expressed in NK cells. {ECO:0000269|PubMed:23269243}. |
Human GZMH full length protein - ab158617 from Abcam
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Human GZMH full length protein - ab202612 from Abcam
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Human GZMH protein fragment - ab158618 from Abcam
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Human GZMH protein fragment - ab158619 from Abcam
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Granzyme H Partial Recombinant Protein - H00002999-Q01 from Novus Biologicals
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Granzyme H Partial Recombinant Protein - H00002999-Q02 from Novus Biologicals
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Granzyme H Recombinant Protein - H00002999-P01 from Novus Biologicals
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Recombinant Human Granzyme H, CF - 1377-SE-010 from R&D Systems
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GZMH Protein Lysate (APL10230) - APL10230 from Aviva Systems Biology
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GZMH Protein Lysate (APL10231) - APL10231 from Aviva Systems Biology
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Granzyme H Blocking Peptide - 33R-6337 from Fitzgerald
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GZMH protein (His tag) - 80R-4173 from Fitzgerald
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Granzyme H (GZMH) (20-246, His-tag) - AR51860PU-N from Acris Antibodies
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Granzyme H (GZMH) (20-246, His-tag) - AR51860PU-S from Acris Antibodies
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Granzyme H (GZMH) - H00002999-P01-10 from Acris Antibodies
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Granzyme H (GZMH) - H00002999-P01-25 from Acris Antibodies
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Granzyme H (GZMH) - H00002999-Q01-10 from Acris Antibodies
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Granzyme H (GZMH) - H00002999-Q01-25 from Acris Antibodies
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Granzyme H (GZMH) - H00002999-Q02 from Acris Antibodies
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Granzyme H (GZMH) - H00002999-Q02-10 from Acris Antibodies
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Granzyme H (GZMH) - H00002999-Q02-25 from Acris Antibodies
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GZMH fusion protein - ag11069 from Proteintech Group
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GZMH fusion protein - Ag11741 from Proteintech Group
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Recombinant Human GZMH, His tagged - GZMH-297H from Creative Biomart
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Granzyme H - PN201644 from Elabscience
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