Gene Symbol | FAM20B |
---|---|
Entrez Gene | 9917 |
Alt Symbol | gxk1 |
Species | Human |
Gene Type | protein-coding |
Description | family with sequence similarity 20, member B |
Other Description | glycosaminoglycan xylosylkinase|xylose kinase |
Swissprots | Q5W0C3 Q5W0C4 O75063 |
Accessions | EAW91034 EAW91035 EAW91036 O75063 AB007944 BAA32320 AB480690 BAH79819 AK289989 BAF82678 BC046441 AAH46441 BC051794 AAH51794 CA844342 XM_011510224 XP_011508526 XM_011510225 XP_011508527 XM_011510226 XP_011508528 NM_014864 NP_055679 |
Function | Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG- protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1- O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized. {ECO:0000269|PubMed:19473117, ECO:0000269|PubMed:24425863}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000269|PubMed:19473117}; Single-pass type II membrane protein {ECO:0000269|PubMed:19473117}. |
Tissue Specificity | Widely expressed. Strongly expressed in pancreas, spleen and fetal liver. {ECO:0000269|PubMed:15676076, ECO:0000269|PubMed:24425863}. |
FAM20B (E-16) - sc-164311 from Santa Cruz Biotechnology
|
||||||||
FAM20B (N-14) - sc-164312 from Santa Cruz Biotechnology
|
||||||||
FAM20B (P-14) - sc-164313 from Santa Cruz Biotechnology
|
||||||||
Anti-FAM20B antibody - ab121261 from Abcam
|
||||||||
FAM20B Antibody - NBP1-81506 from Novus Biologicals
|
||||||||
Anti-FAM20B antibody produced in rabbit - HPA007409 from Sigma-Aldrich
|
||||||||
FAM20B antibody - 14405-1-AP from Proteintech Group
|
||||||||
FAM20B antibody - 19134-1-AP from Proteintech Group
|
||||||||
FAM20B Antibody - EPP12937 from Elabscience
|
||||||||
FAM20B Antibody - EPP12938 from Elabscience
|
||||||||
Anti-FAM20B (aa 258-402) polyclonal antibody - DPABH-16185 from Creative Diagnostics
|
||||||||
Anti-FAM20B monoclonal antibody - DCABH-200534 from Creative Diagnostics
|
||||||||
FAM20B, Polyclonal Antibody - MBS2524990 from MyBioSource
|
||||||||
FAM20B, Polyclonal Antibody - MBS2517403 from MyBioSource
|
||||||||
FAM20B (H-68) - sc-384010 from Santa Cruz Biotechnology
|
||||||||
Recombinant Anti-Human FAM20B Antibody - MOB-3752z from Creative Biolabs
|
||||||||
Recombinant Anti-Human FAM20B Antibody scFv Fragment - MOB-3752z-S(P) from Creative Biolabs
|
||||||||
Recombinant Anti-Human FAM20B Antibody Fab Fragment - MOB-3752z-F(E) from Creative Biolabs
|
||||||||
FAM208B antibody - orb183587 from Biorbyt
|