VANGL2

Gene Symbol VANGL2
Entrez Gene 57216
Alt Symbol LPP1, LTAP, STB1, STBM, STBM1
Species Human
Gene Type protein-coding
Description VANGL planar cell polarity protein 2
Other Description loop-tail protein 1 homolog|loop-tail-associated protein|strabismus 1|van Gogh-like protein 2|vang-like 2 (van gogh, Drosophila)|vang-like protein 2
Swissprots Q5T212 D3DVE9 Q9ULK5
Accessions EAW52717 EAW52718 Q9ULK5 AB033041 BAA86529 AK290981 BAF83670 AL137558 BC103920 BC166628 AAI66628 BG059541 BU162175 BX420618 XM_005245357 XP_005245414 XM_011509804 XP_011508106 XM_011509805 XP_011508107 NM_020335 NP_065068
Function Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q91ZD4}.
Subcellular Location Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Top Pathways Wnt signaling pathway

Vangl2 (H-55) - sc-67136 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Vangl2 (H-55): sc-67136. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.

Vangl2 (M-13) - sc-46560 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Vangl2 (M-13): sc-46560. Western blot analysis of Vangl2 expression in rat brain tissue extract.

Vangl2 (N-13) - sc-46561 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Vangl2 (N-13): sc-46561. Western blot analysis of Vangl2 expression in IMR-32 (A), NIH/3T3 (B) and SK-N-SH (C) whole cell lysates and rat brain tissue extract (D).

Anti-VANGL2 antibody - ab156430 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-VANGL2 antibody (ab156430) at 1/100 dilution + Mouse brain tissue lysate at 35 µg

Anti-VANGL2 antibody - N-terminal - ab198887 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-VANGL2 antibody - N-terminal (ab198887) at 1/250 dilution + NIH 3T3 cell lysate at 40 µgdeveloped using the ECL technique

Anti-VANGL2 antibody - N-terminal - ab181684 from Abcam

Prices $372.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-VANGL2 antibody - ab76174 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-VANGL2 antibody (ab76174) at 1 µg/mlLane 1 :  HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 2 : SHSY-5Y (Human neuroblastoma cell line) Whole Cell Lysate Lane 3 : SK N BE (Human neuroblastoma) Whole Cell Lysate Lane 4 : SK N SH (Human neuroblastoma) Whole Cell Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-VANGL2 antibody - ab60172 from Abcam

Prices $378.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-VANGL2 antibody (ab60172) at 0.3 µg/ml + Mouse Brain lysate (35µg protein in RIPA buffer)

Anti-VANGL2 antibody - ab92897 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VANGL2 / LTAP Antibody (aa241-521) - LS-C76737 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-VANGL2 / LTAP Antibody (aa300-350) - LS-C144268 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-VANGL2 / LTAP Antibody (N-Terminus) - LS-C145108 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-VANGL2 / LTAP Antibody - LS-C154774 from LifeSpan Bioscience

Prices $295.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-VANGL2 / LTAP Antibody (C-Terminus) - LS-C209995 from LifeSpan Bioscience

Prices $295.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-VANGL2 / LTAP Antibody (aa37-65, AP) - LS-C218395 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VANGL2 / LTAP Antibody (aa37-65, APC) - LS-C218397 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VANGL2 / LTAP Antibody (aa37-65, Biotin) - LS-C218398 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VANGL2 / LTAP Antibody (aa37-65, Azide-free, HRP) - LS-C218400 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VANGL2 / LTAP Antibody (aa403-415) - LS-C55662 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.3 ug/ml) staining of Mouse Brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-VANGL2 / LTAP Antibody (aa37-65, FITC) - LS-C218399 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VANGL2 / LTAP Antibody (aa37-65, PE) - LS-C218417 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VANGL2 / LTAP Antibody (N-Terminus) - LS-C209997 from LifeSpan Bioscience

Prices $405.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal
IHC of a zebrafish whole mount probed with anti-Vangl-2 (NT) (image courtesy of Megan Senecal from the University of Utah.)

Anti-VANGL2 / LTAP Antibody (aa37-65) - LS-C326249 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VANGL2 / LTAP Antibody (aa300-350) - LS-C148351 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Van Gogh like-2 in human brain lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse brain and 4) rat brain using LS-C148351 at 5 ug/ml, 6 ug/ml and 5 ug/ml, respectively. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.

Anti-VANGL2 / LTAP Antibody (aa37-65) - LS-C157029 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
VANGL2 Antibody western blot of mouse brain tissue lysates (35 ug/lane). The VANGL2 antibody detected the VANGL2 protein (arrow).
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