Gene Symbol | VANGL2 |
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Entrez Gene | 57216 |
Alt Symbol | LPP1, LTAP, STB1, STBM, STBM1 |
Species | Human |
Gene Type | protein-coding |
Description | VANGL planar cell polarity protein 2 |
Other Description | loop-tail protein 1 homolog|loop-tail-associated protein|strabismus 1|van Gogh-like protein 2|vang-like 2 (van gogh, Drosophila)|vang-like protein 2 |
Swissprots | Q5T212 D3DVE9 Q9ULK5 |
Accessions | EAW52717 EAW52718 Q9ULK5 AB033041 BAA86529 AK290981 BAF83670 AL137558 BC103920 BC166628 AAI66628 BG059541 BU162175 BX420618 XM_005245357 XP_005245414 XM_011509804 XP_011508106 XM_011509805 XP_011508107 NM_020335 NP_065068 |
Function | Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity). {ECO:0000250|UniProtKB:Q91ZD4}. |
Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Top Pathways | Wnt signaling pathway |
Vangl2 (H-55) - sc-67136 from Santa Cruz Biotechnology
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Vangl2 (M-13) - sc-46560 from Santa Cruz Biotechnology
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Vangl2 (N-13) - sc-46561 from Santa Cruz Biotechnology
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Anti-VANGL2 antibody - ab156430 from Abcam
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Anti-VANGL2 antibody - N-terminal - ab198887 from Abcam
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Anti-VANGL2 antibody - N-terminal - ab181684 from Abcam
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Anti-VANGL2 antibody - ab76174 from Abcam
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Anti-VANGL2 antibody - ab60172 from Abcam
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Anti-VANGL2 antibody - ab92897 from Abcam
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Anti-VANGL2 / LTAP Antibody (aa241-521) - LS-C76737 from LifeSpan Bioscience
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Anti-VANGL2 / LTAP Antibody (aa300-350) - LS-C144268 from LifeSpan Bioscience
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Anti-VANGL2 / LTAP Antibody (N-Terminus) - LS-C145108 from LifeSpan Bioscience
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Anti-VANGL2 / LTAP Antibody - LS-C154774 from LifeSpan Bioscience
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Anti-VANGL2 / LTAP Antibody (C-Terminus) - LS-C209995 from LifeSpan Bioscience
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Anti-VANGL2 / LTAP Antibody (aa37-65, AP) - LS-C218395 from LifeSpan Bioscience
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Anti-VANGL2 / LTAP Antibody (aa37-65, APC) - LS-C218397 from LifeSpan Bioscience
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Anti-VANGL2 / LTAP Antibody (aa37-65, Biotin) - LS-C218398 from LifeSpan Bioscience
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Anti-VANGL2 / LTAP Antibody (aa37-65, Azide-free, HRP) - LS-C218400 from LifeSpan Bioscience
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Anti-VANGL2 / LTAP Antibody (aa403-415) - LS-C55662 from LifeSpan Bioscience
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Anti-VANGL2 / LTAP Antibody (aa37-65, FITC) - LS-C218399 from LifeSpan Bioscience
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Anti-VANGL2 / LTAP Antibody (aa37-65, PE) - LS-C218417 from LifeSpan Bioscience
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Anti-VANGL2 / LTAP Antibody (N-Terminus) - LS-C209997 from LifeSpan Bioscience
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Anti-VANGL2 / LTAP Antibody (aa37-65) - LS-C326249 from LifeSpan Bioscience
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Anti-VANGL2 / LTAP Antibody (aa300-350) - LS-C148351 from LifeSpan Bioscience
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Anti-VANGL2 / LTAP Antibody (aa37-65) - LS-C157029 from LifeSpan Bioscience
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