| Gene Symbol |
LPL
|
| Entrez Gene |
4023
|
| Alt Symbol |
HDLCQ11, LIPD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lipoprotein lipase
|
| Other Description |
-
|
| Swissprots |
B2R5T9 P06858 Q96FC4 Q16282 Q16283
|
| Accessions |
AAA59528 AAB20999 AAB21000 AAC61679 AAM23256 AAY85371 CAA48230 EAW63764 P06858 AK092286 BAG52519 AK222464 BAD96184 AK290290 BAF82979 AK297164 BAH12512 AK312311 BAG35236 BC011353 AAH11353 BT006726 AAP35372 CR457054 CAG33335 DA485210 DQ893541 ABM84467 DQ893751 ABM84677 M15856 AAB59536 M26380 S78266 X14390 CAA32564 X54516 CAA38372 NM_000237 NP_000228
|
| Function |
The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Secreted {ECO:0000250}. Note=Locates to the plasma membrane of microvilli of hepatocytes with triacyl- glycerol-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles (By similarity). {ECO:0000250}.
|
| Top Pathways |
Alzheimer's disease, PPAR signaling pathway, Glycerolipid metabolism
|
![Western Blot: Lipoprotein lipase Overexpression Lysate (Adult Normal) [NBL1-12656] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Lipoprotein lipase.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3174_Lipoprotein%2520lipase%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12656-img0002.jpg)