Gene Symbol | CHKA |
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Entrez Gene | 1119 |
Alt Symbol | CHK, CK, CKI, EK |
Species | Human |
Gene Type | protein-coding |
Description | choline kinase alpha |
Other Description | CHETK-alpha|ethanolamine kinase |
Swissprots | P35790 Q8NE29 |
Accessions | EAW74694 EAW74695 EAW74696 P35790 AI809679 AK054792 AK092643 AL834403 BC036471 AAH36471 BE260889 BG703955 BG723115 BI195927 BU617910 D10704 BAA01547 XR_428904 XR_428905 XR_949772 XR_949773 XR_949774 XR_949775 XR_949776 XR_949777 NM_001277 NP_001268 NM_212469 NP_997634 |
Function | Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline. {ECO:0000269|PubMed:19915674}. |
Subcellular Location | Cytoplasm. |
Top Pathways | Choline metabolism in cancer, Glycerophospholipid metabolism |
ChoK CRISPR/Cas9 KO Plasmid (h) - sc-403793 from Santa Cruz Biotechnology
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ChoK HDR Plasmid (h) - sc-403793-HDR from Santa Cruz Biotechnology
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ChoK Double Nickase Plasmid (h) - sc-403793-NIC from Santa Cruz Biotechnology
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ChoK Double Nickase Plasmid (h2) - sc-403793-NIC-2 from Santa Cruz Biotechnology
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ChoK CRISPR Activation Plasmid (h) - sc-403793-ACT from Santa Cruz Biotechnology
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ChoK CRISPR Activation Plasmid (h2) - sc-403793-ACT-2 from Santa Cruz Biotechnology
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ChoK Lentiviral Activation Particles (h) - sc-403793-LAC from Santa Cruz Biotechnology
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ChoK Lentiviral Activation Particles (h2) - sc-403793-LAC-2 from Santa Cruz Biotechnology
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ChoK siRNA (h) - sc-38965 from Santa Cruz Biotechnology
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ChoK shRNA Plasmid (h) - sc-38965-SH from Santa Cruz Biotechnology
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ChoK shRNA (h) Lentiviral Particles - sc-38965-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU066271 from Sigma-Aldrich
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MISSION® siRNA - SIHK0413 from Sigma-Aldrich
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MISSION® siRNA - SIHK0415 from Sigma-Aldrich
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MISSION® siRNA - SIHK0414 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6062 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6062 from Sigma-Aldrich
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CHKA siRNA (Human) - CRH0799 from Cohesion Biosciences
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Choline kinase alpha RNAi - H00001119-R03 from Novus Biologicals
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Choline kinase alpha RNAi - H00001119-R04 from Novus Biologicals
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CHKA - MBS8214839 from MyBioSource
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ChoK CRISPR/Cas9 KO Plasmid (h2) - sc-403793-KO-2 from Santa Cruz Biotechnology
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ChoK HDR Plasmid (h2) - sc-403793-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CHKA (NM_001277.2) - SHH263109 from Creative biogene
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shRNA set against Human CHKA(NM_001277.2) - SHG175177 from Creative biogene
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