MARK1

Gene Symbol MARK1
Entrez Gene 4139
Alt Symbol MARK, Par-1c, Par1c
Species Human
Gene Type protein-coding
Description MAP/microtubule affinity-regulating kinase 1
Other Description PAR1 homolog c|serine/threonine-protein kinase MARK1
Swissprots D3DTB1 Q9P251 Q9P0L2 Q96SW9 Q5VTG0 Q5VTF9 Q2HIY1 D3DTB0
Accessions EAW93298 EAW93299 EAW93300 EAW93301 EAW93302 Q9P0L2 AB040910 BAA96001 AF154845 AAF72103 AK027493 BAB55152 AK098103 AK295506 BAG58425 AK314614 AL512724 CAC21661 BC068608 BC113869 AAI13870 BC114478 AAI14479 CA412112 DB308514 KJ534879 AHW56519 KJ534880 AHW56520 KJ534881 AHW56521 KJ535089 AHW56728 XM_005273134 XP_005273191 XM_006711326 XP_006711389 XM_006711327 XP_006711390 XM_011509561 XP_011507863 XM_011509562 XP_011507864 NM_001286124 NP_001273053 NM_001286126 NP_001273055 NM_001286128 NP_001273057 NM_001286129 NP_001273058 NM_018650 NP_061120
Function Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:21145462}; Peripheral membrane protein {ECO:0000269|PubMed:21145462}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Appears to localize to an intracellular network. {ECO:0000250}.
Tissue Specificity Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney. {ECO:0000269|PubMed:9108484}.

Phospho-MARK Family (Activation Loop) Antibody - 4836 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293 cells transfected with either wild-type or threonine to alanine mutations at the respective phosphorylation sites of the MARK family members, using Phospho-MARK Family (Activation Loop) Antibody. Transfected constructs contain a GST and HA tag. Transfection efficiency monitored with HA Antibody, #2367.

MARK1 Antibody - 3319 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using MARK1 Antibody.

MARK1 (H-50) - sc-366948 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MARK1 (H-50): sc-366948. Western blot analysis of MARK1 expression in KNRK whole cell lysate.

MARK1 (S-20) - sc-70088 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MARK1 (V-17) - sc-70090 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MARK1 (H-23) - sc-130815 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
MARK1 (H-23): sc-130815. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human brain tissue showing cytoplasmic localization.

Anti-MARK1 (phospho T215) antibody [EPR5463] - ab126731 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5463
All lanes : Anti-MARK1 (phospho T215) antibody [EPR5463] (ab126731) at 1/10000 dilutionLane 1 : SH-SY5Y cell lysate, untreatedLane 2 : SH-SY5Y cell lysate, treated with Okadaic acid and Calyculin A Lysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-MARK1 antibody - ab60202 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-MARK1 antibody (ab60202) at 1/250 dilution + P7 mouse whole brain lysate at 60 µg

Anti-MARK1 antibody - ab70128 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MARK1 antibody (ab70128) at 1/500 dilutionLane 1 : Extracts from HeLa cellsLane 2 : Extracts from HeLa cells with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-MARK1 antibody - ab71306 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MARK1 antibody (ab71306)Lane 1 : HeLa cell lysateLane 2 : T47D cell lysateLane 3 : Mouse brain tissue lysate

Anti-MARK1 antibody - C-terminal - ab172880 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-MARK1 antibody - C-terminal (ab172880) at 1/100 dilution + Mouse brain tissue lysate at 35 µg

Anti-MARK1 / MARK Antibody (aa671-700) - LS-C98354 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
The anti-MARK1 C-term antibody is used in Western blot to detect MARK1 in, from left to right, HeLa, T47D, and mouse brain cell line/ tissue lysate.

Anti-MARK1 / MARK Antibody (C-Terminus, AP) - LS-C262665 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MARK1 / MARK Antibody (C-Terminus, Biotin) - LS-C262667 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MARK1 / MARK Antibody (C-Terminus, APC) - LS-C262666 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MARK1 / MARK Antibody (C-Terminus, FITC) - LS-C262668 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MARK1 / MARK Antibody (C-Terminus, Azide-free, HRP) - LS-C262669 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MARK1 / MARK Antibody (aa643-674) - LS-C164038 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
MARK Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-MARK1 / MARK Antibody (aa600-627, AP) - LS-C262671 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MARK1 / MARK Antibody (aa6-40) - LS-C98353 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human brain tissue reacted with MARK1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-MARK1 / MARK Antibody (C-Terminus, PE) - LS-C262670 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MARK1 / MARK Antibody (aa600-627, APC) - LS-C262672 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MARK1 / MARK Antibody (aa600-627, Azide-free, HRP) - LS-C262676 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MARK1 / MARK Antibody (aa600-627, Biotin) - LS-C262673 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MARK1 / MARK Antibody (aa641-671, AP) - LS-C262677 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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