MARK1

Gene Symbol	MARK1
Entrez Gene	4139
Alt Symbol	MARK, Par-1c, Par1c
Species	Human
Gene Type	protein-coding
Description	MAP/microtubule affinity-regulating kinase 1
Other Description	PAR1 homolog c|serine/threonine-protein kinase MARK1
Swissprots	D3DTB1 Q9P251 Q9P0L2 Q96SW9 Q5VTG0 Q5VTF9 Q2HIY1 D3DTB0
Accessions	EAW93298 EAW93299 EAW93300 EAW93301 EAW93302 Q9P0L2 AB040910 BAA96001 AF154845 AAF72103 AK027493 BAB55152 AK098103 AK295506 BAG58425 AK314614 AL512724 CAC21661 BC068608 BC113869 AAI13870 BC114478 AAI14479 CA412112 DB308514 KJ534879 AHW56519 KJ534880 AHW56520 KJ534881 AHW56521 KJ535089 AHW56728 XM_005273134 XP_005273191 XM_006711326 XP_006711389 XM_006711327 XP_006711390 XM_011509561 XP_011507863 XM_011509562 XP_011507864 NM_001286124 NP_001273053 NM_001286126 NP_001273055 NM_001286128 NP_001273057 NM_001286129 NP_001273058 NM_018650 NP_061120
Function	Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:21145462}; Peripheral membrane protein {ECO:0000269|PubMed:21145462}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Appears to localize to an intracellular network. {ECO:0000250}.
Tissue Specificity	Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney. {ECO:0000269|PubMed:9108484}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MARK1 / MARK Antibody Blocking Peptide - LS-E3128 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MARK1 / MARK Antibody Blocking Peptide - LS-E8718 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MARK1 / MARK Antibody Blocking Peptide - LS-E8719 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MARK1 / MARK Antibody Blocking Peptide - LS-E26610 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MARK1 / MARK Antibody Blocking Peptide - LS-E29673 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

MARK1 / MARK Antibody Blocking Peptide - LS-E29671 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

MARK1 / MARK Antibody Blocking Peptide - LS-E29670 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human MARK1 Protein - P4719 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Source Insect Species Human

MARK1 Peptide - P2298 from Novus Biologicals Category Peptide Species Human

MARK1 Peptide - P2297 from Novus Biologicals Category Peptide Species Human

MARK1-Antibody-C-term-Blocking-Peptide - BP7144b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MARK1-Antibody-N-term-Blocking-Peptide - BP7144a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MARK1 - P4719 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

MARK1 - P5726 from Acris Antibodies Category Protein Prices $1,010.00 Sizes 5 µg Species Human

MARK1 fusion protein - Ag16332 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

MARK1 fusion protein - Ag16225 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human MARK1 - MARK1-795H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human MARK1, GST-tagged, Active - MARK1-348H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human MAP/Microtubule Affinity-Regulating Kinase 1, GST-tagged - MARK1-1269H from Creative Biomart Category Protein Source Insect cells Species Human

Recombinant Human MARK1 (Active), GST-tagged - MARK1-1427H from Creative Biomart Category Protein Source Sf9 Cells Species Human

MARK1 Protein, active, 250 µg - 14-651M from EMD Millipore Category Protein Prices $2,544.00 Sizes 250 µg also available in 10 μg size . (cat#14-651) and in bulk (cat# 14-651-K) Source Human MARK1 expressed by baculovirus in Sf21 insect cells.

MARK1 Protein, active, 10 µg - 14-651 from EMD Millipore Category Protein Prices $329.00 Sizes 10 µg Source Human MARK1 expressed by baculovirus in Sf21 insect cells.

MARK Blocking Peptide - CBP3486 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Zebrafish

MARK1/2/3/4 (N211) Peptide - BS3001P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Serine/threonine-protein kinase MARK1(MARK1) - CSB-YP873719HU CSB-EP873719HU CSB-BP873719HU CSB-MP873719HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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