| Gene Symbol |
MARK1
|
| Entrez Gene |
4139
|
| Alt Symbol |
MARK, Par-1c, Par1c
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MAP/microtubule affinity-regulating kinase 1
|
| Other Description |
PAR1 homolog c|serine/threonine-protein kinase MARK1
|
| Swissprots |
D3DTB1 Q9P251 Q9P0L2 Q96SW9 Q5VTG0 Q5VTF9 Q2HIY1 D3DTB0
|
| Accessions |
EAW93298 EAW93299 EAW93300 EAW93301 EAW93302 Q9P0L2 AB040910 BAA96001 AF154845 AAF72103 AK027493 BAB55152 AK098103 AK295506 BAG58425 AK314614 AL512724 CAC21661 BC068608 BC113869 AAI13870 BC114478 AAI14479 CA412112 DB308514 KJ534879 AHW56519 KJ534880 AHW56520 KJ534881 AHW56521 KJ535089 AHW56728 XM_005273134 XP_005273191 XM_006711326 XP_006711389 XM_006711327 XP_006711390 XM_011509561 XP_011507863 XM_011509562 XP_011507864 NM_001286124 NP_001273053 NM_001286126 NP_001273055 NM_001286128 NP_001273057 NM_001286129 NP_001273058 NM_018650 NP_061120
|
| Function |
Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:17573348}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:21145462}; Peripheral membrane protein {ECO:0000269|PubMed:21145462}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Appears to localize to an intracellular network. {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney. {ECO:0000269|PubMed:9108484}.
|