| Gene Symbol |
SCN9A
|
| Entrez Gene |
6335
|
| Alt Symbol |
ETHA, FEB3B, GEFSP7, HSAN2D, NE-NA, NENA, Nav1.7, PN1, SFNP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sodium channel, voltage gated, type IX alpha subunit
|
| Other Description |
hNE-Na|neuroendocrine sodium channel|peripheral sodium channel 1|sodium channel protein type 9 subunit alpha|sodium channel protein type IX subunit alpha|sodium channel, voltage-gated, type IX, alpha polypeptide|sodium channel, voltage-gated, type IX, alpha subunit|voltage-gated sodium channel alpha subunit Nav1.7|voltage-gated sodium channel subunit alpha Nav1.7
|
| Swissprots |
Q70HX2 A1BUH5 Q8WTU1 Q70HX1 Q15858 Q6B4S0 Q6B4R9 Q8WWN4 Q6B4S1
|
| Accessions |
AAY14794 AAZ77737 CAE45644 CAE45645 EAX11314 EAX11315 EAX11316 Q15858 AJ277393 AJ310882 CAC84550 AJ310883 CAC84551 AJ310897 CAC84537 AK307549 AL517958 AY682084 AAT85833 AY682085 AAT85834 AY682086 AAT85835 BU742924 DQ857292 ABI51981 X82835 CAA58042 XM_005246757 XP_005246814 XM_011511616 XP_011509918 XM_011511617 XP_011509919 XM_011511618 XP_011509920 XM_011511619 XP_011509921 NM_002977 NP_002968
|
| Function |
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein. Note=In neurite terminals. {ECO:0000250}.
|
| Tissue Specificity |
Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Isoform 1 is expressed preferentially in the central and peripheral nervous system. Isoform 2 is expressed preferentially in the dorsal root ganglion. {ECO:0000269|PubMed:15178348, ECO:0000269|PubMed:15302875, ECO:0000269|PubMed:7720699, ECO:0000269|PubMed:9169448}.
|