SCN9A

Gene Symbol SCN9A
Entrez Gene 6335
Alt Symbol ETHA, FEB3B, GEFSP7, HSAN2D, NE-NA, NENA, Nav1.7, PN1, SFNP
Species Human
Gene Type protein-coding
Description sodium channel, voltage gated, type IX alpha subunit
Other Description hNE-Na|neuroendocrine sodium channel|peripheral sodium channel 1|sodium channel protein type 9 subunit alpha|sodium channel protein type IX subunit alpha|sodium channel, voltage-gated, type IX, alpha polypeptide|sodium channel, voltage-gated, type IX, alpha subunit|voltage-gated sodium channel alpha subunit Nav1.7|voltage-gated sodium channel subunit alpha Nav1.7
Swissprots Q70HX2 A1BUH5 Q8WTU1 Q70HX1 Q15858 Q6B4S0 Q6B4R9 Q8WWN4 Q6B4S1
Accessions AAY14794 AAZ77737 CAE45644 CAE45645 EAX11314 EAX11315 EAX11316 Q15858 AJ277393 AJ310882 CAC84550 AJ310883 CAC84551 AJ310897 CAC84537 AK307549 AL517958 AY682084 AAT85833 AY682085 AAT85834 AY682086 AAT85835 BU742924 DQ857292 ABI51981 X82835 CAA58042 XM_005246757 XP_005246814 XM_011511616 XP_011509918 XM_011511617 XP_011509919 XM_011511618 XP_011509920 XM_011511619 XP_011509921 NM_002977 NP_002968
Function Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain (By similarity). {ECO:0000250}.
Subcellular Location Membrane; Multi-pass membrane protein. Note=In neurite terminals. {ECO:0000250}.
Tissue Specificity Expressed strongly in dorsal root ganglion, with only minor levels elsewhere in the body, smooth muscle cells, MTC cell line and C-cell carcinoma. Isoform 1 is expressed preferentially in the central and peripheral nervous system. Isoform 2 is expressed preferentially in the dorsal root ganglion. {ECO:0000269|PubMed:15178348, ECO:0000269|PubMed:15302875, ECO:0000269|PubMed:7720699, ECO:0000269|PubMed:9169448}.

Nav1.7 Antibody - 14573 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of mouse and rat brain membrane extracts using Nav1.7 Antibody.

Na + CP type IXα (S-17) - sc-168691 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Na + CP type IXα (H-17) - sc-130096 from Santa Cruz Biotechnology

Prices $295.00
Sizes 50 µg/0.5 ml
Host Rabbit
Clonality Polyclonal

Anti-Nav1.7 antibody - ab65167 from Abcam

Prices $394.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab65167 staining Nav1.7 in human sperm cells by Immunocytochemistry/ Immunofluorescence.Sperm cells were washed, re-suspended in phosphate-buffered saline and smeared onto poly-L-lysine-coated slides. Spermatozoa were then fixed by incubation in cold methanol (-20°C) for 20 minutes. Slides were washed three times for 10 minutes with PBS and incubated with 2% BSA in PBS for 30 minutes to block non-specific sites. Test slides were incubated with ab65167 at a 1/100 dilution. Samples were washed three times in PBS, and incubated for 60 minutes with appropriate FITC-conjugated secondary antibodies. Slides were further washed in PBS, mounted using Vectashield and examined with a Olympus BX-51 fluorescence microscopy using a 100× immersion objective.

Anti-Nav1.7 antibody - ab196806 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Nav1.7 antibody (ab196806) at 1/500 dilutionLane 1 : RAW cell extractLane 2 : RAW cell extract with synthesized peptide

Anti-Nav1.7 antibody - ab140991 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of Formalin-fixed, Paraffin-Embedded Human small intestine (neuroendocrine cells) tissue labelling Nav1.7 with ab140991 at 10 µg/ml.

Anti-Nav1.7 antibody - ab110961 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using anti-Nav1.7 antibody (Q15858). The picture on the right is treated with the synthesized peptide.

Anti-Nav1.7 antibody - ab83767 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-Nav1.7 antibody - ab181774 from Abcam

Prices $372.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Nav1.7 antibody - ab123806 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal

Anti-Nav1.7 antibody [mAbcam62758] - ab62758 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone mAbcam62758
All lanes : Anti-Nav1.7 antibody [mAbcam62758] (ab62758) at 1 µg/mlLane 1 : Spinal Cord (Mouse) Tissue Lysate Lane 2 : Spinal Cord (Rat) Tissue Lysate Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Mouse IgG H&L (HRP) preadsorbed (ab97040) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Nav1.7 antibody [S68-6] - ab85015 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S68-6
Immunohistochemical analysis of Mouse brain tissue labeling Nav1.7 with ab85015 at 1μg/ml.

Anti-SCN9A / Nav1.7 Antibody (clone N68/6) - LS-C124227 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone N68/6

Anti-SCN9A / Nav1.7 Antibody - LS-C144745 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SCN9A / Nav1.7 Antibody - LS-C153554 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCN9A / Nav1.7 Antibody (Arg692) - LS-C193164 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCN9A / Nav1.7 Antibody (aa1874-1887) - LS-C154886 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SCN9A / Nav1.7 Antibody (aa651-700) - LS-C120401 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human lung carcinoma tissue, using SCN9A Antibody. The picture on the right is treated with the synthesized peptide.

Anti-SCN9A / Nav1.7 Antibody (aa1751-1946, clone S68-6, Atto 390) - LS-C230754 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S68-6

Anti-SCN9A / Nav1.7 Antibody (aa1751-1946, clone S68-6, Atto 488) - LS-C230755 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S68-6

Anti-SCN9A / Nav1.7 Antibody (aa1751-1946, clone S68-6, Atto 594) - LS-C230757 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S68-6

Anti-SCN9A / Nav1.7 Antibody (aa1751-1946, clone S68-6, Atto 700) - LS-C230760 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S68-6

Anti-SCN9A / Nav1.7 Antibody (aa1751-1946, clone S68-6, Atto 655) - LS-C230758 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S68-6

Anti-SCN9A / Nav1.7 Antibody (aa1751-1946, clone S68-6, Atto 565) - LS-C230756 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S68-6

Anti-SCN9A / Nav1.7 Antibody (aa1751-1946, clone S68-6, Atto 680) - LS-C230761 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S68-6
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