| Gene Symbol |
RASSF2
|
| Entrez Gene |
9770
|
| Alt Symbol |
CENP-34, RASFADIN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Ras association (RalGDS/AF-6) domain family member 2
|
| Other Description |
Ras association (RalGDS/AF-6) domain family 2|centromere protein 34|ras association domain-containing protein 2
|
| Swissprots |
Q53HD0 A8K5Z3 A6NIX9 P50749 Q8IZA5 Q17S06 Q6AHZ2
|
| Accessions |
EAX10445 P50749 AK222650 BAD96370 AK291458 BAF84147 AK307232 AY154470 AAN59975 AY154471 AAN59976 AY154472 AAN59977 BC110385 AAI10386 BC117118 AAI17119 BC117120 AAI17121 CR627436 CAH10522 D79990 BAA11485 DA333367 HQ258175 ADR82929 XM_005260895 XP_005260952 XM_011529410 XP_011527712 XM_011529411 XP_011527713 XM_011529412 XP_011527714 NM_014737 NP_055552 NM_170774 NP_739580
|
| Function |
Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation. {ECO:0000269|PubMed:12732644, ECO:0000269|PubMed:16012945, ECO:0000269|PubMed:19525978}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Translocates to the cytoplasm in the presence of STK3/MST2 AND STK4/MST1.
|
| Tissue Specificity |
Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines. {ECO:0000269|PubMed:12732644}.
|