Gene Symbol | RASSF2 |
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Entrez Gene | 9770 |
Alt Symbol | CENP-34, RASFADIN |
Species | Human |
Gene Type | protein-coding |
Description | Ras association (RalGDS/AF-6) domain family member 2 |
Other Description | Ras association (RalGDS/AF-6) domain family 2|centromere protein 34|ras association domain-containing protein 2 |
Swissprots | Q53HD0 A8K5Z3 A6NIX9 P50749 Q8IZA5 Q17S06 Q6AHZ2 |
Accessions | EAX10445 P50749 AK222650 BAD96370 AK291458 BAF84147 AK307232 AY154470 AAN59975 AY154471 AAN59976 AY154472 AAN59977 BC110385 AAI10386 BC117118 AAI17119 BC117120 AAI17121 CR627436 CAH10522 D79990 BAA11485 DA333367 HQ258175 ADR82929 XM_005260895 XP_005260952 XM_011529410 XP_011527712 XM_011529411 XP_011527713 XM_011529412 XP_011527714 NM_014737 NP_055552 NM_170774 NP_739580 |
Function | Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation. {ECO:0000269|PubMed:12732644, ECO:0000269|PubMed:16012945, ECO:0000269|PubMed:19525978}. |
Subcellular Location | Nucleus. Cytoplasm. Note=Translocates to the cytoplasm in the presence of STK3/MST2 AND STK4/MST1. |
Tissue Specificity | Widely expressed with highest levels in brain, placenta, peripheral blood and lung. Frequently down-regulated in lung tumor cell lines. {ECO:0000269|PubMed:12732644}. |
RASSF2 CRISPR/Cas9 KO Plasmid (h) - sc-404969 from Santa Cruz Biotechnology
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RASSF2 HDR Plasmid (h) - sc-404969-HDR from Santa Cruz Biotechnology
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RASSF2 Double Nickase Plasmid (h) - sc-404969-NIC from Santa Cruz Biotechnology
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RASSF2 Double Nickase Plasmid (h2) - sc-404969-NIC-2 from Santa Cruz Biotechnology
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RASSF2 CRISPR Activation Plasmid (h) - sc-404969-ACT from Santa Cruz Biotechnology
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RASSF2 CRISPR Activation Plasmid (h2) - sc-404969-ACT-2 from Santa Cruz Biotechnology
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RASSF2 Lentiviral Activation Particles (h) - sc-404969-LAC from Santa Cruz Biotechnology
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RASSF2 Lentiviral Activation Particles (h2) - sc-404969-LAC-2 from Santa Cruz Biotechnology
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RASSF2 siRNA (h) - sc-45722 from Santa Cruz Biotechnology
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RASSF2 shRNA Plasmid (h) - sc-45722-SH from Santa Cruz Biotechnology
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RASSF2 shRNA (h) Lentiviral Particles - sc-45722-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU068601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17996 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17996 from Sigma-Aldrich
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RASSF2 siRNA (Human) - CRH6533 from Cohesion Biosciences
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RASSF2 - MBS8230604 from MyBioSource
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shRNA set against Human RASSF2 (NM_014737.2) - SHH390164 from Creative biogene
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Human RASSF2 siRNA - orb267035 from Biorbyt
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RASSF2 shRNA Plasmid (Human) - CHH6533 from Cohesion Biosciences
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RASSF2 miRNA 3'UTR clone - MiUTR4H-TG07348 from Creative biogene
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