| Gene Symbol | TMED9 |
|---|---|
| Entrez Gene | 54732 |
| Alt Symbol | GMP25, HSGP25L2G, p25 |
| Species | Human |
| Gene Type | protein-coding |
| Description | transmembrane emp24 protein transport domain containing 9 |
| Other Description | glycoprotein 25L2|gp25L2 protein|p24 family protein alpha-2|p24alpha2|transmembrane emp24 domain-containing protein 9 |
| Swissprots | Q8WZ61 Q14437 Q9BVK6 |
| Accessions | EAW84966 EAW84967 EAW84968 Q9BVK6 AF441399 AAL35268 AK298435 BAG60656 AK313292 BAG36099 BC001123 AAH01123 BG830564 X90872 CAA62380 NM_017510 NP_059980 |
| Function | Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer- dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB. {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:14600267, ECO:0000269|PubMed:16595549, ECO:0000269|PubMed:18287528, ECO:0000269|PubMed:19296914}. |
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Cycles between compartments of the early secretatory pathway. |