TMED9
| Gene Symbol | TMED9 |
|---|---|
| Entrez Gene | 54732 |
| Alt Symbol | GMP25, HSGP25L2G, p25 |
| Species | Human |
| Gene Type | protein-coding |
| Description | transmembrane emp24 protein transport domain containing 9 |
| Other Description | glycoprotein 25L2|gp25L2 protein|p24 family protein alpha-2|p24alpha2|transmembrane emp24 domain-containing protein 9 |
| Swissprots | Q8WZ61 Q14437 Q9BVK6 |
| Accessions | EAW84966 EAW84967 EAW84968 Q9BVK6 AF441399 AAL35268 AK298435 BAG60656 AK313292 BAG36099 BC001123 AAH01123 BG830564 X90872 CAA62380 NM_017510 NP_059980 |
| Function | Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer- dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB. {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:14600267, ECO:0000269|PubMed:16595549, ECO:0000269|PubMed:18287528, ECO:0000269|PubMed:19296914}. |
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Cycles between compartments of the early secretatory pathway. |
TMED9 CRISPR/Cas9 KO Plasmid (h) - sc-407215 from Santa Cruz Biotechnology
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TMED9 HDR Plasmid (h) - sc-407215-HDR from Santa Cruz Biotechnology
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TMED9 Double Nickase Plasmid (h) - sc-407215-NIC from Santa Cruz Biotechnology
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TMED9 Double Nickase Plasmid (h2) - sc-407215-NIC-2 from Santa Cruz Biotechnology
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TMED9 CRISPR Activation Plasmid (h) - sc-407215-ACT from Santa Cruz Biotechnology
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TMED9 CRISPR Activation Plasmid (h2) - sc-407215-ACT-2 from Santa Cruz Biotechnology
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TMED9 Lentiviral Activation Particles (h) - sc-407215-LAC from Santa Cruz Biotechnology
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TMED9 Lentiviral Activation Particles (h2) - sc-407215-LAC-2 from Santa Cruz Biotechnology
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TMED9 siRNA (h) - sc-91723 from Santa Cruz Biotechnology
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TMED9 shRNA Plasmid (h) - sc-91723-SH from Santa Cruz Biotechnology
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TMED9 shRNA (h) Lentiviral Particles - sc-91723-V from Santa Cruz Biotechnology
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TMED9 RNAi - H00054732-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN21461 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21461 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05727 from Sigma-Aldrich
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TMED9 siRNA (Human) - CRJ0186 from Cohesion Biosciences
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TMED9 - MBS828275 from MyBioSource
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TMED9 CRISPR/Cas9 KO Plasmid (h2) - sc-407215-KO-2 from Santa Cruz Biotechnology
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TMED9 HDR Plasmid (h2) - sc-407215-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human TMED9 (NM_017510.4) - SHH428664 from Creative biogene
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shRNA set against Human TMED9(NM_017510.4) - SHL075432 from Creative biogene
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Human TMED9 siRNA - orb270687 from Biorbyt
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TMED9 shRNA Plasmid (Human) - CHJ0186 from Cohesion Biosciences
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TMED9 miRNA 3'UTR clone - MiUTR1H-10467 from Creative biogene
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