| Gene Symbol | SIPA1L1 |
|---|---|
| Entrez Gene | 26037 |
| Alt Symbol | E6TP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | signal-induced proliferation-associated 1 like 1 |
| Other Description | SIPA1-like protein 1|high-risk human papilloma viruses E6 oncoproteins targeted protein 1|signal-induced proliferation-associated 1-like protein 1 |
| Swissprots | Q9UNU4 O95321 O43166 Q9UDU4 J3KP19 |
| Accessions | AAC83179 CAD12684 CAD12685 CAD12686 CAD12687 CCA64007 CCA64575 EAW81058 EAW81059 EAW81060 O43166 AB007900 BAA23712 AF090989 AAD12543 AF090990 AAD12544 AK094532 AK122930 AK302650 BAG63889 BC033950 BC146777 AAI46778 CR936651 CAI56789 DA330003 XM_005267516 XP_005267573 XM_005267519 XP_005267576 XM_006720109 XP_006720172 XM_006720111 XP_006720174 XM_006720112 XP_006720175 XM_011536630 XP_011534932 XM_011536631 XP_011534933 XM_011536632 XP_011534934 XM_011536633 XP_011534935 XM_011536634 XP_011534936 XM_011536635 XP_011534937 XM_011536636 XP_011534938 XM_011536637 XP_011534939 XM_011536638 XP_011534940 XM_011536639 XP_011534941 NM_001284245 NP_001271174 NM_001284246 NP_001271175 NM_001284247 NP_001271176 NM_015556 NP_056371 |
| Function | Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F- actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons (By similarity). {ECO:0000250}. |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:9858596}. |
| Top Pathways | Rap1 signaling pathway |
E6TP1 CRISPR/Cas9 KO Plasmid (h) - sc-403670 from Santa Cruz Biotechnology
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E6TP1 HDR Plasmid (h) - sc-403670-HDR from Santa Cruz Biotechnology
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E6TP1 Double Nickase Plasmid (h) - sc-403670-NIC from Santa Cruz Biotechnology
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E6TP1 Double Nickase Plasmid (h2) - sc-403670-NIC-2 from Santa Cruz Biotechnology
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E6TP1 CRISPR Activation Plasmid (h) - sc-403670-ACT from Santa Cruz Biotechnology
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E6TP1 CRISPR Activation Plasmid (h2) - sc-403670-ACT-2 from Santa Cruz Biotechnology
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E6TP1 Lentiviral Activation Particles (h) - sc-403670-LAC from Santa Cruz Biotechnology
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E6TP1 Lentiviral Activation Particles (h2) - sc-403670-LAC-2 from Santa Cruz Biotechnology
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E6TP1 siRNA (h) - sc-42180 from Santa Cruz Biotechnology
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E6TP1 shRNA Plasmid (h) - sc-42180-SH from Santa Cruz Biotechnology
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E6TP1 shRNA (h) Lentiviral Particles - sc-42180-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU001611 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19351 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19351 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02742 from Sigma-Aldrich
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SIPA1L1 siRNA (Human) - CRH8670 from Cohesion Biosciences
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SIPA1L1 - MBS8232198 from MyBioSource
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shRNA set against Human Sipa1l1 (NM_015556.1) - SHH407656 from Creative biogene
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shRNA set against Human SIPA1L1(NM_015556.1) - SHR226068 from Creative biogene
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SIPA1L1 shRNA Plasmid (Human) - CHH8670 from Cohesion Biosciences
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SIPA1L1 miRNA 3'UTR clone - MiUTR1H-09405 from Creative biogene
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