IGF1R

Gene Symbol	IGF1R
Entrez Gene	3480
Alt Symbol	CD221, IGFIR, IGFR, JTK13
Species	Human
Gene Type	protein-coding
Description	insulin-like growth factor 1 receptor
Other Description	IGF-I receptor|insulin-like growth factor I receptor|soluble IGF1R variant 1|soluble IGF1R variant 2
Swissprots	Q14CV2 B1B5Y2 Q9UCC0 P08069
Accessions	AAB59399 AAP81165 CAJ55819 EAX02220 EAX02221 EAX02222 P08069 AB425196 BAG11657 AF020763 AAB97676 AK310188 AY429545 BC010607 BC078157 BC088377 BC107089 AAI07090 BC111046 BC113610 AAI13611 BC113612 AAI13613 BC143721 AAI43722 BM264223 BQ185364 BX093045 CN414655 DA486252 DR007209 EU826611 ACF47647 EU826612 ACF47648 X04434 CAA28030 XM_011521513 XP_011519815 XM_011521514 XP_011519816 XM_011521515 XP_011519817 XM_011521516 XP_011519818 XM_011521517 XP_011519819 NM_000875 NP_000866 NM_001291858 NP_001278787 NM_152452
Function	Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downs
Subcellular Location	Cell membrane {ECO:0000269|PubMed:17524361}; Single-pass type I membrane protein {ECO:0000269|PubMed:17524361}.
Tissue Specificity	Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues. Overexpressed in tumors, including melanomas, cancers of the colon, pancreas prostate and kidney. {ECO:0000269|PubMed:12019176, ECO:0000269|PubMed:8247543, ECO:0000269|PubMed:9202395, ECO:0000269|PubMed:9355755}.
Top Pathways	Focal adhesion, Proteoglycans in cancer, Long-term depression, Rap1 signaling pathway, Melanoma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Phospho-IGF-I Receptor β (Tyr1131) Sandwich ELISA Antibody Pair - 7820 from Cell Signaling Technology Category Antibody Pair Prices $459.00 Sizes 1 kit (Reagents for 4 x 96 well plates)

PathScan ® Phospho-IGF-I Receptor β (Tyr1131) Sandwich ELISA Kit - 7302 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® RTK Signaling Antibody Array Kit (Chemiluminescent Readout) - 7982 from Cell Signaling Technology Category Antibody Array Prices $609.00 Sizes 1 kit (16 multiplexed assays)

PathScan ® RTK Signaling Antibody Array Kit (Fluorescent Readout) - 7949 from Cell Signaling Technology Category Antibody Array Prices $649.00 Sizes 1 kit (16 multiplexed assays)

HTScan® IGF-1 Receptor Kinase Assay Kit - 7746 from Cell Signaling Technology Category Assay Kit

IGF1 Receptor Human ELISA Kit - ab100546 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 6 pg/ml Range 8.23 pg/ml - 6000 pg/ml

Human IGF1R / IGF1 Receptor ELISA Kit (Sandwich ELISA) - LS-F7034 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.126 ng/ml Range 250-16000 pg/ml

Mouse/Human/Rat Phospho-IGF1R / IGF1 Receptor (Tyr1161) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1066 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 250-16000 pg/ml

Mouse/Human/Rat IGF1R / IGF1 Receptor ELISA Kit (Cell-Based ELISA) - LS-F2068 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 250-16000 pg/ml

Human IGF1R / IGF1 Receptor ELISA Kit (Sandwich ELISA) - LS-F989 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 250-16000 pg/ml

Mouse/Human/Rat Phospho-IGF1R / IGF1 Receptor (Tyr1165, Tyr1166) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1536 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 250-16000 pg/ml

Rat IGF1R / IGF1 Receptor ELISA Kit (Sandwich ELISA) - LS-F9043 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.062 ng/ml Range 250-16000 pg/ml

Mouse IGF1R / IGF1 Receptor ELISA Kit (Sandwich ELISA) - LS-F9875 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 250-16000 pg/ml

Human IGF1R / IGF1 Receptor ELISA Kit (Sandwich ELISA) - LS-F10484 from LifeSpan Bioscience Category ELISA Kit Prices $570.00 Sizes 1 plate Sensitivity 10 pg/ml Range 250-16000 pg/ml

Human IGF1R / IGF1 Receptor ELISA Kit (Sandwich ELISA) - LS-F11724 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 250-16000 pg/ml

Human IGF-I R ELISA Kit - RAB0230 from Sigma-Aldrich Category ELISA Kit Prices $423.50 Sizes 1 kt

Human Phospho-IGF-I R DuoSet IC Economy Pk, 15 Plate - DYC1770E from R&D Systems Category ELISA Kit

Human Phospho-IGF-I R DuoSet IC ELISA - DYC1770-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00, $1,425.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates), 1 pack (for 15 Plates)

Human Phospho-IGF-I R DuoSet IC, 5 Plate - DYC1770-5 from R&D Systems Category ELISA Kit

Human Total IGF-I R DuoSet IC ELISA - DYC305-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates) Range 156.00 - 10,000 pg/mL

Human Total IGF-I R DuoSet IC, 5 Plate - DYC305-5 from R&D Systems Category ELISA Kit

Human IGF-I R DuoSet ELISA - DY391 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 250.00 - 16,000 pg/mL

Human IGF1R ELISA kit - 55R-2083 from Fitzgerald Category ELISA Kit Prices $505.00 Sizes 96 tests

IGF-1R ELISA Kit (Human) : 96 Wells (OKAG00126) - OKAG00126 from Aviva Systems Biology Category ELISA Kit Prices $390.00 Sizes 96 wells Sensitivity 250 pg/mL Range 250-16,000 pg/mL

Human IGF1R ELISA Kit - abx151907 from Abbexa Category ELISA Kit Sensitivity 0.105 ng/ml Range 0.313 ng/ml - 20 ng/ml

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