IGF1R

Gene Symbol	IGF1R
Entrez Gene	3480
Alt Symbol	CD221, IGFIR, IGFR, JTK13
Species	Human
Gene Type	protein-coding
Description	insulin-like growth factor 1 receptor
Other Description	IGF-I receptor|insulin-like growth factor I receptor|soluble IGF1R variant 1|soluble IGF1R variant 2
Swissprots	Q14CV2 B1B5Y2 Q9UCC0 P08069
Accessions	AAB59399 AAP81165 CAJ55819 EAX02220 EAX02221 EAX02222 P08069 AB425196 BAG11657 AF020763 AAB97676 AK310188 AY429545 BC010607 BC078157 BC088377 BC107089 AAI07090 BC111046 BC113610 AAI13611 BC113612 AAI13613 BC143721 AAI43722 BM264223 BQ185364 BX093045 CN414655 DA486252 DR007209 EU826611 ACF47647 EU826612 ACF47648 X04434 CAA28030 XM_011521513 XP_011519815 XM_011521514 XP_011519816 XM_011521515 XP_011519817 XM_011521516 XP_011519818 XM_011521517 XP_011519819 NM_000875 NP_000866 NM_001291858 NP_001278787 NM_152452
Function	Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downs
Subcellular Location	Cell membrane {ECO:0000269|PubMed:17524361}; Single-pass type I membrane protein {ECO:0000269|PubMed:17524361}.
Tissue Specificity	Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues. Overexpressed in tumors, including melanomas, cancers of the colon, pancreas prostate and kidney. {ECO:0000269|PubMed:12019176, ECO:0000269|PubMed:8247543, ECO:0000269|PubMed:9202395, ECO:0000269|PubMed:9355755}.
Top Pathways	Focal adhesion, Proteoglycans in cancer, Long-term depression, Rap1 signaling pathway, Melanoma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence® IGF-I Receptor siRNA I - 6610 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

IGF-IR CRISPR/Cas9 KO Plasmid (h) - sc-400084 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IGF-IR HDR Plasmid (h) - sc-400084-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IGF-IR Double Nickase Plasmid (h) - sc-400084-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IGF-IR Double Nickase Plasmid (h2) - sc-400084-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IGF-IR CRISPR Activation Plasmid (h) - sc-400084-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IGF-IR CRISPR Activation Plasmid (h2) - sc-400084-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IGF-IR Lentiviral Activation Particles (h) - sc-400084-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IGF-IR Lentiviral Activation Particles (h2) - sc-400084-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IGF-IRα/β siRNA (h) - sc-29358 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IGF-IRα/β shRNA Plasmid (h) - sc-29358-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IGF-IRα/β shRNA (h) Lentiviral Particles - sc-29358-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IGF-I R RNAi - H00003480-R04 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU028861 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0934 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0933 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0932 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1268 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1268 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

IGF1R siRNA (Human) - CRH2351 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

IGF1R - MBS8218699 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human IGF1R(NM_000875.3) - SHL167934 from Creative biogene Category siRNA Species Reactivities Human

Human IGF1R siRNA - orb262853 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

IGF1R shRNA Plasmid (Human) - CHH2351 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

IGF1R miRNA 3'UTR clone - MiUTR1H-04832 from Creative biogene Species Reactivities Human

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