IGF1R

Gene Symbol	IGF1R
Entrez Gene	3480
Alt Symbol	CD221, IGFIR, IGFR, JTK13
Species	Human
Gene Type	protein-coding
Description	insulin-like growth factor 1 receptor
Other Description	IGF-I receptor|insulin-like growth factor I receptor|soluble IGF1R variant 1|soluble IGF1R variant 2
Swissprots	Q14CV2 B1B5Y2 Q9UCC0 P08069
Accessions	AAB59399 AAP81165 CAJ55819 EAX02220 EAX02221 EAX02222 P08069 AB425196 BAG11657 AF020763 AAB97676 AK310188 AY429545 BC010607 BC078157 BC088377 BC107089 AAI07090 BC111046 BC113610 AAI13611 BC113612 AAI13613 BC143721 AAI43722 BM264223 BQ185364 BX093045 CN414655 DA486252 DR007209 EU826611 ACF47647 EU826612 ACF47648 X04434 CAA28030 XM_011521513 XP_011519815 XM_011521514 XP_011519816 XM_011521515 XP_011519817 XM_011521516 XP_011519818 XM_011521517 XP_011519819 NM_000875 NP_000866 NM_001291858 NP_001278787 NM_152452
Function	Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downs
Subcellular Location	Cell membrane {ECO:0000269|PubMed:17524361}; Single-pass type I membrane protein {ECO:0000269|PubMed:17524361}.
Tissue Specificity	Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues. Overexpressed in tumors, including melanomas, cancers of the colon, pancreas prostate and kidney. {ECO:0000269|PubMed:12019176, ECO:0000269|PubMed:8247543, ECO:0000269|PubMed:9202395, ECO:0000269|PubMed:9355755}.
Top Pathways	Focal adhesion, Proteoglycans in cancer, Long-term depression, Rap1 signaling pathway, Melanoma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human IGF1 Receptor beta subunit protein fragment - ab80349 from Abcam Category Protein Prices $341.00 Sizes 10 µg Source Insect cells Species Human

Active human IGF1 Receptor protein fragment - ab155622 from Abcam Category Protein Prices $352.00 Sizes 100 µg Source HEK 293 cells Species Human

Active IGF1 Receptor protein fragment - ab71657 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Insect cells

Human IGF1 Receptor (phospho Y1161) peptide - ab99365 from Abcam Category Peptide

Human IGF1 Receptor peptide - ab101732 from Abcam Category Peptide

Human IGF1 Receptor peptide - ab118178 from Abcam Category Peptide

Human IGF1 Receptor protein fragment - ab83637 from Abcam Category Protein Source E. coli Species Human

IGF1R / IGF1 Receptor Antibody Blocking Peptide - LS-E10594 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IGF1R / IGF1 Receptor Antibody Blocking Peptide - LS-E9149 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IGF-I R Blocking Peptide - NBP1-77680PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

IGF-I R Partial Recombinant Protein - H00003480-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human IGF-I R Protein - P4702 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Source Insect Species Human

IGF-I R Recombinant Protein - H00003480-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

IGF-I R Recombinant Protein - P3678 from Novus Biologicals Category Protein Prices $689.00 Sizes 20 µg Species Human

IGF-I R Peptide - P2679 from Novus Biologicals Category Peptide Species Human

IGF-I R Peptide - P2678 from Novus Biologicals Category Peptide Species Human

IGF-I R Recombinant Protein - P4860 from Novus Biologicals Category Protein Prices $799.00 Sizes 10 µg Species Human

IGF1-Receptor-IGF1R-Antibody-C-term-Blocking-peptide - BP7649b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IGF1-Receptor-IGF1R-Antibody-N-term-Blocking-peptide - BP7649a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human IGF-I R, CF - 391-GR-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Met1-Asn932

Recombinant Human IGF-I R (Histidine-tagged), CF - 305-GR-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Met1-Asn932 with a C-terminal 10-His tag

Recombinant human Insulin-like growth factor 1 receptor (OPCA00749) - OPCA00749 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

IGF-IR Protein (OPPA01150) - OPPA01150 from Aviva Systems Biology Category Protein Prices $315.00 Sizes 2 µg Source E. Coli

Human IGF1R protein - orb246365 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human CD221 protein - orb139077 from Biorbyt Category Protein Prices $434.00, $612.00 Sizes 50 μg, 100 μg Source Baculovirus-Insect Cells Species Human

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