| Gene Symbol | IGF1R |
|---|---|
| Entrez Gene | 3480 |
| Alt Symbol | CD221, IGFIR, IGFR, JTK13 |
| Species | Human |
| Gene Type | protein-coding |
| Description | insulin-like growth factor 1 receptor |
| Other Description | IGF-I receptor|insulin-like growth factor I receptor|soluble IGF1R variant 1|soluble IGF1R variant 2 |
| Swissprots | Q14CV2 B1B5Y2 Q9UCC0 P08069 |
| Accessions | AAB59399 AAP81165 CAJ55819 EAX02220 EAX02221 EAX02222 P08069 AB425196 BAG11657 AF020763 AAB97676 AK310188 AY429545 BC010607 BC078157 BC088377 BC107089 AAI07090 BC111046 BC113610 AAI13611 BC113612 AAI13613 BC143721 AAI43722 BM264223 BQ185364 BX093045 CN414655 DA486252 DR007209 EU826611 ACF47647 EU826612 ACF47648 X04434 CAA28030 XM_011521513 XP_011519815 XM_011521514 XP_011519816 XM_011521515 XP_011519817 XM_011521516 XP_011519818 XM_011521517 XP_011519819 NM_000875 NP_000866 NM_001291858 NP_001278787 NM_152452 |
| Function | Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downs |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:17524361}; Single-pass type I membrane protein {ECO:0000269|PubMed:17524361}. |
| Tissue Specificity | Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues. Overexpressed in tumors, including melanomas, cancers of the colon, pancreas prostate and kidney. {ECO:0000269|PubMed:12019176, ECO:0000269|PubMed:8247543, ECO:0000269|PubMed:9202395, ECO:0000269|PubMed:9355755}. |
| Top Pathways | Focal adhesion, Proteoglycans in cancer, Long-term depression, Rap1 signaling pathway, Melanoma |