Gene Symbol | Nrp1 |
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Entrez Gene | 18186 |
Alt Symbol | C530029I03, NP-1, NPN-1, Npn1, Nrp |
Species | Mouse |
Gene Type | protein-coding |
Description | neuropilin 1 |
Other Description | A5 protein|Neuropilin-1 precursor (A5 protein)|neuropilin-1|transmembrane receptor |
Swissprots | Q6PAR3 P97333 |
Accessions | AAP78928 CAI84569 CAM55895 EDL11827 EDL11828 P97333 AK002673 AK011144 AK030358 AK040447 AK082992 AK083052 AK135428 AK141964 BAE24901 AK148372 BAE28513 AK149752 AK159219 AK164378 AK171933 AK179138 AK188315 AK192303 AK207791 AK216801 BC006184 BC026730 BC032048 BC038657 BC051447 AAH51447 BC060129 AAH60129 D50086 BAA08789 XM_006530766 XP_006530829 XM_006530767 XP_006530830 XM_006530768 XP_006530831 NM_008737 NP_032763 |
Function | Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis (By similarity). {ECO:0000250}. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Nervous system. |
Top Pathways | Axon guidance, HTLV-I infection |
neuropilin CRISPR/Cas9 KO Plasmid (m) - sc-421964 from Santa Cruz Biotechnology
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neuropilin HDR Plasmid (m) - sc-421964-HDR from Santa Cruz Biotechnology
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neuropilin Double Nickase Plasmid (m) - sc-421964-NIC from Santa Cruz Biotechnology
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neuropilin Double Nickase Plasmid (m2) - sc-421964-NIC-2 from Santa Cruz Biotechnology
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neuropilin CRISPR Activation Plasmid (m) - sc-421964-ACT from Santa Cruz Biotechnology
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neuropilin CRISPR Activation Plasmid (m2) - sc-421964-ACT-2 from Santa Cruz Biotechnology
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neuropilin Lentiviral Activation Particles (m) - sc-421964-LAC from Santa Cruz Biotechnology
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neuropilin Lentiviral Activation Particles (m2) - sc-421964-LAC-2 from Santa Cruz Biotechnology
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neuropilin siRNA (m) - sc-36039 from Santa Cruz Biotechnology
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neuropilin shRNA Plasmid (m) - sc-36039-SH from Santa Cruz Biotechnology
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neuropilin shRNA (m) Lentiviral Particles - sc-36039-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN36695 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND36695 from Sigma-Aldrich
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NRP1 siRNA (Mouse) - CRM2841 from Cohesion Biosciences
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shRNA set against Mouse NRP1 (NM_008737.2) - SHH355200 from Creative biogene
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Mouse NRP1 siRNA - orb282317 from Biorbyt
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NRP1 shRNA Plasmid (Mouse) - CHM2841 from Cohesion Biosciences
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