PMEPA1

Gene Symbol	PMEPA1
Entrez Gene	56937
Alt Symbol	STAG1, TMEPAI
Species	Human
Gene Type	protein-coding
Description	prostate transmembrane protein, androgen induced 1
Other Description	prostate transmembrane protein androgen induced 1|protein TMEPAI|solid tumor-associated 1 protein|transmembrane, prostate androgen induced RNA
Swissprots	Q9UJD3 Q5TDR6 Q96B72 Q8NER4 Q969W9
Accessions	AAL09357 EAW75504 EAW75505 EAW75506 EAW75507 EAW75508 Q969W9 AF224278 AAF86322 AF305616 AAL16781 AJ308020 AJ308021 AK024618 AK296199 BAG58927 AL732104 AL732105 AY128643 AAM89277 BC015918 AAH15918 BC025361 BC080635 AAH80635 BM846677 BQ008707 BQ690750 BU196912 NM_001255976 NP_001242905 NM_020182 NP_064567 NM_199169 NP_954638 NM_199170 NP_954639 NM_199171 NP_954640
Function	Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514). {ECO:0000269|PubMed:18703514, ECO:0000269|PubMed:20129061, ECO:0000269|PubMed:24627487}.
Subcellular Location	Early endosome membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
Tissue Specificity	Highest expression in prostate. Also expressed in ovary.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PMEPA1 (P-15) - sc-85829 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-TMEPAI antibody - ab128006 from Abcam Prices $407.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TMEPAI antibody - ab57503 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-TMEPAI antibody - ab81531 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-TMEPAI / PMEPA1 Antibody (aa75-124) - LS-C200502 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TMEPAI / PMEPA1 Antibody (aa101-150) IHC-plus™ - LS-B6326 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

TMEPAI Antibody - NBP1-55696 from Novus Biologicals Prices $229.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

TMEPAI Antibody (2A12) - H00056937-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2A12

TMEPAI Antibody - NBP2-41321 from Novus Biologicals Prices $329.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-TMEPA antibody produced in rabbit - SAB4502441 from Sigma-Aldrich Prices $335.50 Sizes 100 µg Host Rabbit Clonality Polyclonal

STAG1 Antibody - N-terminal region (ARP52120_P050) - ARP52120_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

TMEPAI-Antibody-monoclonal-M01 - AT4265a from Abgent, a WuXi AppTec company Prices $315.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2A12

PMEPA1 Antibody (OAAF02602) - OAAF02602 from Aviva Systems Biology Prices $289.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

PMEPA1 Antibody (OAAF06948) - OAAF06948 from Aviva Systems Biology Prices $289.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

PMEPA1 antibody - orb126259 from Biorbyt Prices $85.00, $255.00, $425.00 Sizes 25 μg (Trial Size), 100 μg, 200 μg Host Rabbit Clonality Polyclonal

TMEPA antibody - 70R-32061 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

PMEPA1 Antibody - abx008093 from Abbexa Host Rabbit Clonality Polyclonal

PMEPA1 Antibody - abx013748 from Abbexa Host Rabbit Clonality Polyclonal

PMEPA1 / STAG1 antibody - 16521-1-AP from Acris Antibodies Prices $270.00 Sizes 150 µl Host Rabbit Clonality Polyclonal

PMEPA1 / STAG1 antibody - AP10352PU-N from Acris Antibodies Prices $390.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

PMEPA1 / STAG1 antibody - AP31759PU-N from Acris Antibodies Prices $430.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

PMEPA1 / STAG1 antibody - H00056937-M01 from Acris Antibodies Prices $360.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2A12

Rabbit Anti-Human TMEPAI / PMEPA1 (Internal) - 119-15761 from RayBiotech Host Rabbit

PMEPA1 Antibody - 70-624 from ProSci Prices $375.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

PMEPA1 Antibody - 8261 from ProSci Prices $79.00, $325.00 Sizes 20 µg, 100 µg Host Rabbit Clonality Polyclonal

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