| Gene Symbol |
PMEPA1
|
| Entrez Gene |
56937
|
| Alt Symbol |
STAG1, TMEPAI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
prostate transmembrane protein, androgen induced 1
|
| Other Description |
prostate transmembrane protein androgen induced 1|protein TMEPAI|solid tumor-associated 1 protein|transmembrane, prostate androgen induced RNA
|
| Swissprots |
Q9UJD3 Q5TDR6 Q96B72 Q8NER4 Q969W9
|
| Accessions |
AAL09357 EAW75504 EAW75505 EAW75506 EAW75507 EAW75508 Q969W9 AF224278 AAF86322 AF305616 AAL16781 AJ308020 AJ308021 AK024618 AK296199 BAG58927 AL732104 AL732105 AY128643 AAM89277 BC015918 AAH15918 BC025361 BC080635 AAH80635 BM846677 BQ008707 BQ690750 BU196912 NM_001255976 NP_001242905 NM_020182 NP_064567 NM_199169 NP_954638 NM_199170 NP_954639 NM_199171 NP_954640
|
| Function |
Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514). {ECO:0000269|PubMed:18703514, ECO:0000269|PubMed:20129061, ECO:0000269|PubMed:24627487}.
|
| Subcellular Location |
Early endosome membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
|
| Tissue Specificity |
Highest expression in prostate. Also expressed in ovary.
|