PMEPA1

Gene Symbol	PMEPA1
Entrez Gene	56937
Alt Symbol	STAG1, TMEPAI
Species	Human
Gene Type	protein-coding
Description	prostate transmembrane protein, androgen induced 1
Other Description	prostate transmembrane protein androgen induced 1|protein TMEPAI|solid tumor-associated 1 protein|transmembrane, prostate androgen induced RNA
Swissprots	Q9UJD3 Q5TDR6 Q96B72 Q8NER4 Q969W9
Accessions	AAL09357 EAW75504 EAW75505 EAW75506 EAW75507 EAW75508 Q969W9 AF224278 AAF86322 AF305616 AAL16781 AJ308020 AJ308021 AK024618 AK296199 BAG58927 AL732104 AL732105 AY128643 AAM89277 BC015918 AAH15918 BC025361 BC080635 AAH80635 BM846677 BQ008707 BQ690750 BU196912 NM_001255976 NP_001242905 NM_020182 NP_064567 NM_199169 NP_954638 NM_199170 NP_954639 NM_199171 NP_954640
Function	Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514). {ECO:0000269|PubMed:18703514, ECO:0000269|PubMed:20129061, ECO:0000269|PubMed:24627487}.
Subcellular Location	Early endosome membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
Tissue Specificity	Highest expression in prostate. Also expressed in ovary.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TMEPAI protein fragment - ab163440 from Abcam Category Protein Source Wheat germ Species Human

STAG1 / SA1 Antibody Blocking Peptide - LS-E4340 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TMEPAI Partial Recombinant Protein - H00056937-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human SA1 Protein - H00010274-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PMEPA1 peptide - orb218589 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human

PMEPA1 Blocking Peptide - abx063920 from Abbexa Category Peptide Species Human

PMEPA1 / STAG1 - H00056937-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PMEPA1 / STAG1 - H00056937-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PMEPA1 / STAG1 Control Peptide - AP10352CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 100 µg

PMEPA1 Peptide - 8261P from ProSci Category Peptide Species Human

PMEPA1 fusion protein - Ag9744 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human PMEPA1, GST-tagged - PMEPA1-1804H from Creative Biomart Category Protein Source E.coli Species Human

PMEPA1 Blocking Peptide - CBP2726 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

Recombinant Human Transmembrane prostate androgen-induced protein(PMEPA1) - CSB-YP822170HU CSB-EP822170HU CSB-BP822170HU CSB-MP822170HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PMEPA1 / STAG1 (transcript variant 4) - TP310261 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

PMEPA1 / STAG1 (transcript variant 3) - TP320162 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

SA1 Recombinant Protein Antigen - NBP1-87097PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PMEPA1 Peptide, Human - M34GP12000H from Creative Peptides Category Peptide Source Synthetic. Species Human

STAG1 Peptide, Human - M34GP15261H from Creative Peptides Category Peptide Source Synthetic. Species Human

PMEPA1 Blocking Peptide - CBP7528 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

PMEPA1 peptide - orb382433 from Biorbyt Category Peptide Prices $196.00, $510.00 Sizes 1 mg, 5 mg Species Human

SA1 Recombinant Protein Antigen - NBP2-54976PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TMEPAI Recombinant Protein Antigen - NBP2-56657PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

STAG1 fusion protein - Ag27603 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

Search more