| Gene Symbol |
FGD4
|
| Entrez Gene |
121512
|
| Alt Symbol |
CMT4H, FRABP, ZFYVE6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
FYVE, RhoGEF and PH domain containing 4
|
| Other Description |
FGD1 family, member 4|FGD1-related F-actin-binding protein|FYVE, RhoGEF and PH domain-containing protein 4|actin-filament binding protein frabin|zinc finger FYVE domain-containing protein 6
|
| Swissprots |
Q6ULS2 Q96M96 Q8TCP6
|
| Accessions |
CCQ43836 EAW88528 EAW88529 EAW88530 Q96M96 AK057294 BAB71413 AK091689 AK124654 AK297025 BAH12479 AK303334 BAH13945 AL713762 CAD28532 AL832064 AY367054 AAQ72372 BC039708 BC045552 AAH45552 BC063403 BC096746 BI756188 DA657803 DB446722 XM_005253304 XP_005253361 XM_005253307 XP_005253364 XM_005253308 XP_005253365 XM_005253309 XP_005253366 XM_005253310 XP_005253367 XM_011520554 XP_011518856 XM_011520555 XP_011518857 XM_011520556 XP_011518858 XM_011520557 XP_011518859 XM_011520558 XP_011518860 XM_011520559 XP_011518861 NM_001304480 NP_001291409 NM_001304481 NP_001291410 NM_001304483 NP_001291412 NM_001304484 NP_001291413 NM_139241 NP_640334
|
| Function |
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Note=Concentrated in filopodia and poorly detected at lamellipodia. Binds along the sides of actin fibers (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in different tissues, including brain, cerebellum, peripheral nerve, skeletal muscle, heart, uterus, placenta and testis. {ECO:0000269|PubMed:17564959}.
|
![Western Blot: FGD4 Overexpression Lysate (Adult Normal) [NBL1-10686] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FGD4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3251_FGD4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10686-img0002.jpg)