Gene Symbol | DUSP4 |
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Entrez Gene | 1846 |
Alt Symbol | HVH2, MKP-2, MKP2, TYP |
Species | Human |
Gene Type | protein-coding |
Description | dual specificity phosphatase 4 |
Other Description | MAP kinase phosphatase 2|VH1 homologous phosphatase 2|dual specificity protein phosphatase 4|dual specificity protein phosphatase hVH2|mitogen-activated protein kinase phosphatase 2|serine/threonine specific protein phosphatase |
Swissprots | Q13115 G5E930 Q13524 D3DSU4 B2RBU5 |
Accessions | EAW63481 EAW63482 EAW63483 EAW63484 Q13115 AI123616 AK314820 BAG37342 AL137704 BC002671 AAH02671 BC012900 BC014565 AAH14565 BG760517 BU742141 DA645190 EU831463 ACE87150 EU831550 ACE86469 S80632 AAB35870 U21108 AAA85119 U48807 AAC50452 XM_011544428 XP_011542730 NM_001394 NP_001385 NM_057158 NP_476499 |
Function | Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. |
Subcellular Location | Nucleus. |
Top Pathways | MAPK signaling pathway |
MKP-2 CRISPR/Cas9 KO Plasmid (h) - sc-401479 from Santa Cruz Biotechnology
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MKP-2 HDR Plasmid (h) - sc-401479-HDR from Santa Cruz Biotechnology
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MKP-2 Double Nickase Plasmid (h) - sc-401479-NIC from Santa Cruz Biotechnology
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MKP-2 Double Nickase Plasmid (h2) - sc-401479-NIC-2 from Santa Cruz Biotechnology
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MKP-2 CRISPR Activation Plasmid (h) - sc-401479-ACT from Santa Cruz Biotechnology
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MKP-2 CRISPR Activation Plasmid (h2) - sc-401479-ACT-2 from Santa Cruz Biotechnology
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MKP-2 Lentiviral Activation Particles (h) - sc-401479-LAC from Santa Cruz Biotechnology
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MKP-2 Lentiviral Activation Particles (h2) - sc-401479-LAC-2 from Santa Cruz Biotechnology
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MKP-2 siRNA (h) - sc-38998 from Santa Cruz Biotechnology
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MKP-2 shRNA Plasmid (h) - sc-38998-SH from Santa Cruz Biotechnology
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MKP-2 shRNA (h) Lentiviral Particles - sc-38998-V from Santa Cruz Biotechnology
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DUSP4 RNAi - H00001846-R01 from Novus Biologicals
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DUSP4 RNAi - H00001846-R02 from Novus Biologicals
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MISSION® esiRNA - EHU059741 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0948 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0138 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0137 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0136 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7558 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7558 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07447 from Sigma-Aldrich
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DUSP4 siRNA (Human) - CRH1294 from Cohesion Biosciences
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DUSP4 - MBS8241305 from MyBioSource
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MKP-2 CRISPR/Cas9 KO Plasmid (h2) - sc-401479-KO-2 from Santa Cruz Biotechnology
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MKP-2 HDR Plasmid (h2) - sc-401479-HDR-2 from Santa Cruz Biotechnology
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