RNF168

Gene Symbol	RNF168
Entrez Gene	165918
Alt Symbol	hRNF168
Species	Human
Gene Type	protein-coding
Description	ring finger protein 168, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase RNF168
Swissprots	Q96NS4 Q8IYW5 Q8NA67
Accessions	EAW53649 EAW53650 EAW53651 Q8IYW5 AK054732 BAB70801 AK093113 BAC04060 AK097068 BC017442 BC029433 BC033791 AAH33791 BC047483 XM_011512489 XP_011510791 NM_152617 NP_689830
Function	E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8- dependent H2A ubiquitination, promoting the formation of 'Lys-63'- linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Al
Subcellular Location	Nucleus {ECO:0000269|PubMed:19203578, ECO:0000269|PubMed:19203579, ECO:0000269|PubMed:19500350, ECO:0000269|PubMed:21041483, ECO:0000269|PubMed:22742833}. Note=Localizes to double-strand breaks (DSBs) sites of DNA damage.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RNF168 full length protein - ab153613 from Abcam Category Protein Source Wheat germ Species Human

Human RNF168 protein fragment - ab153614 from Abcam Category Protein Source Wheat germ Species Human

RNF168 Antibody Blocking Peptide - LS-E4889 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF168 Antibody Blocking Peptide - LS-E15982 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF168 Antibody Blocking Peptide - LS-E30693 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human RNF168 Protein - H00165918-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human RNF168 Protein - H00165918-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RNF168 Blocking Peptide - NBP1-76324PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

RNF168-Antibody-C-term-Blocking-Peptide - BP17270b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RNF168 Peptide - GTX85018-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

RNF168 Blocking Peptide - 33R-6996 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RNF168 - H00165918-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RNF168 - H00165918-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RNF168 - H00165918-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RNF168 - H00165918-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RNF168 Control Peptide - AP30735CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

RNF168 Peptide - 5147P from ProSci Category Peptide Species Human

RNF168 fusion protein - Ag16055 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

RNF168 fusion protein - ag15890 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human RNF168, GST-tagged - RNF168-2338H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human E3 ubiquitin-protein ligase RNF168(RNF168) - CSB-YP814236HU CSB-EP814236HU CSB-BP814236HU CSB-MP814236HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RNF168 - TP307642 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RNF168 Peptide, Human - M34GP13401H from Creative Peptides Category Peptide Source Synthetic. Species Human

RNF168 Recombinant Protein Antigen - NBP2-54959PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

E3 ubiquitin-protein ligase RNF168 (RNF168), Recombinant Protein - MBS1398571 from MyBioSource Category Protein Prices $1,370.00, $1,370.00, $1,585.00, $1,585.00, $2,280.00, $2,280.00, $2,740.00, $2,740.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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