RNF168

Gene Symbol RNF168
Entrez Gene 165918
Alt Symbol hRNF168
Species Human
Gene Type protein-coding
Description ring finger protein 168, E3 ubiquitin protein ligase
Other Description E3 ubiquitin-protein ligase RNF168
Swissprots Q96NS4 Q8IYW5 Q8NA67
Accessions EAW53649 EAW53650 EAW53651 Q8IYW5 AK054732 BAB70801 AK093113 BAC04060 AK097068 BC017442 BC029433 BC033791 AAH33791 BC047483 XM_011512489 XP_011510791 NM_152617 NP_689830
Function E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8- dependent H2A ubiquitination, promoting the formation of 'Lys-63'- linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Al
Subcellular Location Nucleus {ECO:0000269|PubMed:19203578, ECO:0000269|PubMed:19203579, ECO:0000269|PubMed:19500350, ECO:0000269|PubMed:21041483, ECO:0000269|PubMed:22742833}. Note=Localizes to double-strand breaks (DSBs) sites of DNA damage.

RNF168 (C-13) - sc-100119 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

RNF168 (B-11) - sc-101125 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
RNF168 (B-11): sc-101125. Western blot analysis of RNF168 expression in HeLa whole cell lysate.

Anti-RNF168 antibody - ab58063 from Abcam

Prices $380.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-RNF168 antibody (ab58063) at 1 µg/ml (HepG2 cell lysate)

Anti-RNF168 antibody - ab106389 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-RNF168 antibody (ab106389) at 1 µg/ml + Human Brain Tissue Lysate at 15 µg

Anti-RNF168 antibody - ab103491 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-RNF168 antibody (ab103491) at 5 µg/ml + Human liver lysate at 50 µg

Anti-RNF168 antibody - ab151955 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-RNF168 antibody (ab151955) at 1/1000 dilution + PC3 whole cell lysate at 30 µg

Anti-RNF168 Antibody (aa468-496, APC) - LS-C240107 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RNF168 Antibody (C-Terminus) - LS-C108507 from LifeSpan Bioscience

Prices $325.00, $890.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Western blot of RNF168 in human brain tissue lysate with RNF168 antibody at 1 ug/ml.

Anti-RNF168 Antibody (aa468-496, AP) - LS-C240108 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RNF168 Antibody (aa468-496, Biotin) - LS-C240109 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RNF168 Antibody (aa468-496, FITC) - LS-C240110 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RNF168 Antibody (aa468-496, PE) - LS-C240114 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RNF168 Antibody (aa468-496, Azide-free, HRP) - LS-C248023 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RNF168 Antibody (aa467-496) - LS-C324732 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-RNF168 Antibody (aa462-572, Azide-free) - LS-C328549 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-RNF168 Antibody (aa401-450) - LS-C82462 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
RNF168 antibody LS-C82462 was used in IHC to stain formalin-fixed, paraffin-embedded human brain.

Anti-RNF168 Antibody (aa468-496) - LS-C158871 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
RNF168 Antibody western blot of 293 cell line lysates (35 ug/lane). The RNF168 antibody detected the RNF168 protein (arrow).

Anti-RNF168 Antibody (clone 3E1) - LS-C133844 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3E1
Immunoperoxidase of monoclonal antibody to RNF168 on formalin-fixed paraffin-embedded human prostate cancer. [antibody concentration 1.5 ug/ml]

RNF168 Antibody [Unconjugated] - AF7217 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Western blot shows lysates of mouse brain (cortex) tissue and mouse brain (thalamus/hypothalamus) tissue. PVDF membrane was probed with 0.5 µg/mL of Sheep Anti-Mouse RNF168 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7217) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for RNF168 at approximately 65 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

RNF168 Antibody - NBP1-55075 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: RNF168 Antibody [NBP1-55075] - HepG2 cell lysate, concentration 0.5 ug/ml.

RNF168 Antibody (3E1) - H00165918-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3E1
Western Blot: RNF168 Antibody (3E1) [H00165918-M01] - RNF168 monoclonal antibody (M01), clone 3E1 Analysis of RNF168 expression in HepG2.

RNF168 Antibody - H00165918-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: RNF168 Antibody [H00165918-B01P] - Analysis of RNF168 expression in transfected 293T cell line by RNF168 polyclonal antibody. Lane 1: RNF168 transfected lysate(62.81 KDa). Lane 2: Non-transfected lysate.

RNF168 Antibody - NBP1-76324 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

RNF168 Antibody - H00165918-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: RNF168 Antibody [H00165918-D01P] - Analysis of RNF168 expression in human liver.

RNF168 Antibody - NBP2-20178 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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