| Gene Symbol |
APOBEC3C
|
| Entrez Gene |
27350
|
| Alt Symbol |
A3C, APOBEC1L, ARDC2, ARDC4, ARP5, PBI, bK150C2.3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
|
| Other Description |
DNA dC->dU-editing enzyme APOBEC-3C|apolipoprotein B editing enzyme catalytic polypeptide-like 3C|phorbolin I|probable DNA dC->dU-editing enzyme APOBEC-3C
|
| Swissprots |
Q96F12 B2R884 Q5JZ92 Q7Z2N7 Q9NRW3
|
| Accessions |
CAH05304 EAW60283 EAW60284 Q9NRW3 AB208979 BAD92216 AF165520 AAF86650 AK094570 AK313272 BAG36081 BC011739 AAH11739 BC021080 CR456394 CAG30280 CU012952 CAK54383 CU013240 CAK54682 KC329528 AGI04216 NM_014508 NP_055323
|
| Function |
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the m
|
| Subcellular Location |
Nucleus. Cytoplasm.
|
| Tissue Specificity |
Expressed in spleen, testes, peripherical blood lymphocytes, heart, thymus, prostate and ovary. {ECO:0000269|PubMed:11863358, ECO:0000269|PubMed:20308164}.
|
