Gene Symbol | APOBEC3C |
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Entrez Gene | 27350 |
Alt Symbol | A3C, APOBEC1L, ARDC2, ARDC4, ARP5, PBI, bK150C2.3 |
Species | Human |
Gene Type | protein-coding |
Description | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C |
Other Description | DNA dC->dU-editing enzyme APOBEC-3C|apolipoprotein B editing enzyme catalytic polypeptide-like 3C|phorbolin I|probable DNA dC->dU-editing enzyme APOBEC-3C |
Swissprots | Q96F12 B2R884 Q5JZ92 Q7Z2N7 Q9NRW3 |
Accessions | CAH05304 EAW60283 EAW60284 Q9NRW3 AB208979 BAD92216 AF165520 AAF86650 AK094570 AK313272 BAG36081 BC011739 AAH11739 BC021080 CR456394 CAG30280 CU012952 CAK54383 CU013240 CAK54682 KC329528 AGI04216 NM_014508 NP_055323 |
Function | DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the m |
Subcellular Location | Nucleus. Cytoplasm. |
Tissue Specificity | Expressed in spleen, testes, peripherical blood lymphocytes, heart, thymus, prostate and ovary. {ECO:0000269|PubMed:11863358, ECO:0000269|PubMed:20308164}. |
Human APOBEC3C full length protein - ab162154 from Abcam
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Human APOBEC3C protein fragment - ab162155 from Abcam
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APOBEC3C Antibody Blocking Peptide - LS-E26599 from LifeSpan Bioscience
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ARP5 / ANGPTL6 Antibody Blocking Peptide - LS-E9249 from LifeSpan Bioscience
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Recombinant Human APOBEC3C Protein - H00027350-P01 from Novus Biologicals
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Recombinant Human APOBEC3C Protein - H00027350-Q01 from Novus Biologicals
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APOBEC3C (C-term) blocking peptide - GTX88604-PEP from GeneTex
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APOBEC3C blocking peptide - GTX88659-PEP from GeneTex
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APOBEC3C Blocking Peptide - abx161018 from Abbexa
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APOBEC3C - C-terminal Peptide - AC21-1435-P from Abcore
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APOBEC3C - H00027350-P01 from Acris Antibodies
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APOBEC3C - H00027350-Q01-10 from Acris Antibodies
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APOBEC3C - H00027350-Q01-25 from Acris Antibodies
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APOBEC3C Peptide - 42-743P from ProSci
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APOBEC3C fusion protein - Ag0886 from Proteintech Group
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Recombinant Human APOBEC3C, GST-tagged - APOBEC3C-9755H from Creative Biomart
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APOBEC3C Blocking Peptide - CBP3517 from Cohesion Biosciences
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Recombinant Angiopoietin Like Protein 6 (ANGPTL6) - RPN468Hu01 from Cloud-clone
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Recombinant Human Probable DNA dC->dU-editing enzyme APOBEC-3C(APOBEC3C) - CSB-YP889097HU CSB-EP889097HU CSB-BP889097HU CSB-MP889097HU from Cusabio
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APOBEC3C - TP303971 from Acris Antibodies
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Probable DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C), Recombinant Protein - MBS1400886 from MyBioSource
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Probable DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C), Recombinant Protein - MBS1310086 from MyBioSource
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APOBEC3C, Peptide - MBS428427 from MyBioSource
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APOBEC3C (C-term), Peptide - MBS425131 from MyBioSource
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APOBEC3C-Antibody-C-term-Blocking-peptide - BP10252b from Abgent, a WuXi AppTec company
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